Safety and Efficacy of High-dose Daily Vitamin D3 Supplementation in Children and Young Adults With Sickle Cell Disease.
J Pediatr Hematol Oncol. 2015 May 13. [Epub ahead of print]
Dougherty KA1, Bertolaso C, Schall JI, Smith-Whitley K, Stallings VA.
1*The School of Health Sciences, The Richard Stockton College of New Jersey, Galloway, NJ †University Hospital Umberto I, Sapienza University, Rome, Italy ‡Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition §Division of Hematology, Children's Hospital of Philadelphia ∥Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
see also Sickle cell and Omega-3 at bottom of this page
Black children with sickle cell disease
7,000 IU daily for 12 weeks
All children then had > 20 ng of vitamin D
Less than half of children had > 32 ng of vitamin D
Speculation by VitaminDWiki
Does sickle cell disease, like MS and Diabetes, consume vitamin D?
See also VitaminDWiki
Search VitaminDWiki for "SICKLE CELL" 222 items as of May 2015
Items in both categories of Bone Health and Dark Skin
- Vitamin D should be an almost universal feature of the care of young adults with sickle cell disease – May 2018
- Vitamin D paradox – Blacks need Vit D for health, but not as much D for strong bones – May 2018
- Sickle Cell clinical trial will inject 300,000 IU of vitamin D – RCT due 2020
- Sickle Cell children need more than 7,000 IU of vitamin D daily – May 2015
- Overview Sickle Cell and Vitamin D
- Sickle cell vitamin D deficiency corrected with loading dose – July 2014
- Bone density does not decrease with lower vitamin D levels in blacks as it does in whites – April 2014
- Vitamin D different relationship between whites and blacks for bone and plaque – June 2012
- Sickle cell and low vitamin D – 3 presentations Dec 2012
- Forearm fracture 3.5X more often in black children with low levels of vitamin D – Sept 2012
- Sickle Cell Anemia: 64 percent had less than 10ng of vitamin D – April 2012
- Black seniors near equator: increased vitamin D decreases bone density – Sept 2011
- 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain
- Blacks may not need as much Vitamin D (for their bones)
- Low vitamin D before orthopedic surgery – dark skin 5X more likely – Oct 2010
- Arthritis 2X as severe in African-Americans - April 2010
Suboptimal vitamin D (vit D) status (<32 ng/mL) is ubiquitous among African American children with type SS sickle cell disease (SCD-SS). The vit D supplemental dose to normalize vit D status is unknown. Five to 20-year-old African American children with (n=21) and without (n=23) SCD-SS were randomized to vit D3 supplementation (4000 or 7000 IU/d) and evaluated at 6 and 12 weeks for changes in vit D and SCD status. A dose was considered unsafe if serum calcium was elevated associated with elevated serum 25 hydroxyvitamin D (25(OH)D). At baseline 95% of subjects with SCD-SS and 87% of healthy controls had suboptimal vit D status (mean±SD, 19.2±7.2 and 22.3±9.3 ng/mL, respectively). After 12 weeks supplementation, both D3 doses were safe and well tolerated. Neither group achieved the a priori efficacy criterion of 25(OH)D≥32 ng/mL in >80% of subjects (45% in SCD-SS and 63% in controls). However, for both subjects with SCD-SS and healthy subjects by 12 weeks, deficient (<20 ng/mL) vit D status was eliminated only in those receiving 7000 IU/d. For subjects with SCD-SS, by 12 weeks there was a significant (all P<0.05) increase in fetal hemoglobin, decrease in high-sensitivity C-reactive protein, and reduction in the percentage of subjects with a high platelet count.
Results: Omega-3 treatment reduced the median
- rate of clinical vaso-occlusive events (0 compared with 1.0 per year, P , 0.0001),
- severe anemia (3.2% compared with 16.4%; P , 0.05),
- blood transfusion (4.5% compared with 16.4%; P , 0.05),
- white blood cell count (14.4 6 3.3 compared with 15.6 6 4.0 3103 /mL; P , 0.05), and the
- OR of the inability to attend school at least once during the study period because of illness related to the disease
to 0.4 (95% CI: 0.2, 0.9; P , 0.05).