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Off topic: Baby-sized aspirin doubles chance of getting wet macular degeneration

Just yesterday I happened to again mention to my wife that taking baby aspirin does not really help much (decreases chance of a heart attack by about 10%) but should not hurt either, I was wrong!!.

New York Times Dec 19, 2012 commented on an article in JAMA.

Taking baby aspirin on a regular basis (at least twice a week) was found to raise neovascular macular degeneration from 1 in 200 to 1 in 100. DOUBLE!!

From JAMA

Results The median duration of follow-up was 14.8 years. There were 512 incident cases of early AMD (of 6243 person-visits at risk) and 117 incident cases of late AMD (of 8621 person-visits at risk) over the course of the study. Regular aspirin use 10 years prior to retinal examination was associated with late AMD (hazard ratio [HR], 1.63 [95% CI, 1.01-2.63]; P = .05), with estimated incidence of 1.76% (95% CI, 1.17%-2.64%) in regular users and 1.03% (95% CI, 0.70%-1.51%) in nonusers. For subtypes of late AMD, regular aspirin use 10 years prior to retinal examination was significantly associated with neovascular AMD (HR, 2.20 [95% CI, 1.20-4.15]; P = .01) but not pure geographic atrophy (HR, 0.66 [95% CI, 0.25-1.95]; P = .45). Aspirin use 5 years (HR, 0.86 [95% CI, 0.71-1.05]; P = .13) or 10 years (HR, 0.86 [95% CI, 0.65-1.13]; P = .28) prior to retinal examination was not associated with incident early AMD.

Conclusions Among an adult cohort, aspirin use 5 years prior to observed incidence was not associated with incident early or late AMD.
However, regular aspirin use 10 years prior was associated with a small but statistically significant increase in the risk of incident late and neovascular AMD.

Comment by VitaminDWiki

How can they call a 2.2X increased probability small?
neovascular macular degeneration = wet AMD
Thus: baby aspirin: Provides a 220% increase in AMD in order to get a 6% decrease in blood clots
Note: my father-in-law:

  • used to smoke (4x increase probability - see NYT below) and
  • takes baby-sized aspirin daily (2x increase probability)    got wet macular degeneration 8 years ago
    I have suggested that he stop taking baby aspirin, as it might stop any clotting needed in the macula to stop the bleeding

See also VitaminDWiki

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