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Macula in eyes of seniors were 3.7X more likely to be thin if low vitamin D - July 2014

Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study.

Invest Ophthalmol Vis Sci. 2014 Jul 15. pii: IOVS-14-13918. doi: 10.1167/iovs.14-13918. [Epub ahead of print]
Graffe A1, Beauchet O2, Fantino B3, Milea D1, Annweiler C4.
1Ophthalmology, Angers University Hospital, Angers, 49933, France.
2Geriatrics, Angers University Hospital, Angers, 49933, France.
3Neuroscience, Angers university Hospital, Angers, 49933, France.
4Neuroscience, Angers University Hospital, 4, rue Larrey, Angers, 49933, France ceannweiler at chu-angers.fr.

Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction.

Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% female) included in the GAIT study (ClinicalTrials.gov number, NCT01315717) were separated into 2 groups according to serum 25OHD level (i.e., insufficient<50nmol/L or sufficient≥50nmol/L). The macular thickness was measured on 1000µm central macula with optical coherence tomography, and further binarized according to normal values of macular thickness (i.e., 267.74μm for males, and 255.60μm for females). Age, gender, number of comorbidities, cognitive disorders, body mass index, mean arterial pressure, visual acuity, intraocular pressure, serum calcium concentration and season of testing were considered as potential confounders.

Results. The mean serum 25OHD concentration was 61.2±26.3nmol/L. Patients with vitamin D insufficiency had a reduced macular thickness compared to those without

  • 232.9±40.4µm versus
  • 253.3±32.1 μm, P=0.042.

After adjustment for potential confounders, vitamin D insufficiency was associated with a decreased macular thickness (ß=-59.4μm, P=0.001). Consistently, the participants with vitamin D insufficiency had a 3.7-fold higher risk of having abnormally low macular thickness compared to those with sufficient 25OHD level (P=0.042).

Conclusions. Vitamin D insufficiency was associated with reduced macular thickness among older patients with no patent macular dysfunction. This implies that vitamin D insufficiency may be involved in macular thinning, and provides a scientific base for vitamin D replacement trials in age-related macular degeneration.

PMID: 25028353


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4149 Macular thickness.pdf PDF 2014 admin 17 Jul, 2014 15:52 204.35 Kb 821
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