The Role of Naturopathic Medicine During Active Surveillance in Prostate Cancer
CAND Journal. 2025;32(2):41-49. https://doi.org/10.54434/candj.204
Megan Sandri,1 ND, Daniel Lander,1 ND
Background: Active surveillance (AS) is increasingly used in low-risk prostate cancer, presenting an opportunity for integrative interventions to delay progression and improve overall health. This review explores the role of diet, exercise, and nutritional supplements in AS.
Methods: A narrative review of clinical and observational studies on dietary patterns, physical activity (PA), and nutritional supplements in AS and pre-surgical prostate cancer research.
Results: Plant-based and Mediterranean diets may reduce Gleason-grade progression, though randomized controlled trials (RCTs) show mixed results. Exercise, particularly high-intensity interval training (HIIT), may influence prostate-specific antigen (PSA) kinetics. Nutritional supplements such as vitamin D, green tea polyphenols, lycopene, mushroom mycelium extract, glucoraphanin, and fish oil show potential but inconsistent effects. Cardiovascular disease mortality surpasses prostate cancer mortality in men with localized disease, underscoring the need for cardiometabolic support alongside AS. Multimodal approaches integrating diet, exercise, and supplementation may offer the greatest benefit.
Conclusion: While no single intervention is proven to prevent prostate cancer progression, a comprehensive, personalized approach, including diet, exercise, and additional integrative therapies, may optimize outcomes in motivated patients. Future research should focus on evaluating multimodal integrative strategies in AS.
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VitaminDWki - Cancer - Prostate
Table of Contents June 2025
Prostate Cancer overview
9 Prostate Cancer meta-analyses
7 Prostate Cancer and Dark Skin studies
3 Prostate Cancer and Calcium studies
7 Vitamin D Receptor and Prostate Cancer studies
3 Prostate Cancer and Vitamin D Binding Protein studies
18+ Vitamin D Binding Protein studies with CANCER in the title
17+ Omega-3 and Cancer studies
See also in VitaminDWiki
- Overview Prostate Cancer and Vitamin D
- The use of Vitamin D to prevent prostate cancer doubled in a decade – May 2019
- Prostate and Urinary systems much better with higher vitamin D – many studies
- Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019
- Low-Grade Prostate Cancer 70 percent less likely to progress if good level of Omega-3 – June 2018
- Men with High Omega-3 ratio 3 times less likely to have high grade prostate cancer – July 2019