25-Hydroxyvitamin D in the Range of 20 to 100 ng/mL and Incidence of Kidney Stones
Stacie Nguyen, MPH, Leo Baggerly, PhD, Christine French, MS, Robert P. Heaney, MD, Edward D. Gorham, PhD, and Cedric F. Garland, DrPH
Stacie Nguyen, Leo Baggerly, and Christine French are with GrassrootsHealth, Encinitas, CA. Robert P. Heaney is with Creighton University, Osteoporosis Research Center, Omaha, NE. Edward D. Gorham and Cedric F. Garland are with the Department of Family and Preventive Medicine, University of California San Diego, La Jolla.
Correspondence should be sent to Cedric F. Garland, Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Dr #0620, La Jolla, CA 92093-0620 (e-mail: cgarland at ucsd.edu).
Objectives. Increasing 25-hydroxyvitamin D serum levels can prevent a wide range of diseases. There is a concern about increasing kidney stone risk with vitamin D supplementation. We used GrassrootsHealth data to examine the relationship between vitamin D status and kidney stone incidence.
Methods. The study included 2012 participants followed prospectively for a median of 19 months. Thirteen individuals self-reported kidney stones during the study period. Multivariate logistic regression was applied to assess the association between vitamin D status and kidney stones.
Results. We found no statistically significant association between serum 25-hydroxyvitamin D and kidney stones (P = .42). Body mass index was significantly associated with kidney stone risk (odds ratio = 3.5; 95% confidence interval = 1.1, 11.3).
Conclusions. We concluded that a serum 25-hydroxyvitamin D level of 20 to 100 nanograms per milliliter has no significant association with kidney stone incidence. (Am J Public Health. Published online ahead of print October 17, 2013: e1–e5. doi:10.2105/AJPH.2013.301368)
Same data from GrassRoots Jan 2014
Short url = http://is.gd/ksvitd
PDF is attached at the bottom of this page
See also VitaminDWiki
- Overview Kidney Stones and vitamin D
Rate of Kidney stones appears to increase with Calcium and decrease with Vitamin K2 and Magnesium - Kidney stones associated with higher vitamin D (but not agree how much 20-100 ng) – meta-analysis March 2016
See also bottom of this page
Less than 400 IU of vitamin D (which is typically less than 20 ng shown in this paper) can cause Kidney Stones