Association between serum vitamin D levels and the risk of kidney stone: evidence from a meta-analysis.
Nutr J. 2016 Mar 31;15(1):32. doi: 10.1186/s12937-016-0148-y.
Wang H1, Man L2, Li G2, Huang G2, Liu N2.
1Department of Urology, Beijing Jishuitan Hospital, No. 31, East Xinjiekou Street, Xicheng District, 100035, Beijing, PR China. wanghai150701 at 163.com.
2Department of Urology, Beijing Jishuitan Hospital, No. 31, East Xinjiekou Street, Xicheng District, 100035, Beijing, PR China.
- Huge disagreement between the studies in this meta-analysis as to how much vitamin D is associated with Kidney Stones. One might say that vitamin D is independant of Kidney stones, as an earlier study said
- Kidney stones independant of vitamin D levels in range 20-100 ng – Oct 2013
- Overview Kidney Stones and vitamin D
Rate of Kidney stones appears to increase with Calcium and decrease with Vitamin K2 and Magnesium
- Kidney stones Vitamin D myth from medical book - 2010
Many epidemiological studies have conducted to evaluate the association between serum vitamin D levels and the risk of kidney stone. The aim of this study was to summarize the evidence from epidemiological studies between them.
Pertinent studies were identified by a search of PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI) and China Biology Medical literature up to July 2015. Standardized mean difference (SMD) was conducted to combine the results. Random-effect model was used. Publication bias was estimated using Egger's regression asymmetry test.
Seven articles involving 451 kidney stone cases and 482 controls were included in this meta-analysis. Our pooled results suggested that kidney stone patients had a significantly higher serum vitamin D level compared with controls [summary SMD = 0.65, 95 % CI = 0.51, 0.79, I(2) = 97.0 %]. The associations were also significant both in Europe [SMD = 0.35, 95 % CI = 0.17, 0.53] and in Asia [SMD = 1.00, 95 % CI = 0.76, 1.25]. No publication bias was found.
Our analysis indicated that serum vitamin D level in kidney stone patients was significantly higher than that in non-kidney stone controls, both in Europe and Asia populations.