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Kidney stones (Calcium) associated with lower vitamin D this time – April 2016

Analysis of vitamin D deficiency in calcium stone-forming patients.


Int Urol Nephrol. 2016 Apr 19. [Epub ahead of print]


Girón-Prieto MS1, Del Carmen Cano-García M2, Arrabal-Polo MÁ3, Poyatos-Andujar A4, Quesada-Charneco M5, de Haro-Muñoz T6, Arias-Santiago S7, Arrabal-Martín M8.
1Primary Care, Health Centre of Pinos Puente, Programa de Doctorado de Medicina Clínica y Salud Pública, Granada University, Granada, Spain.
2Institute IBS Granada, Plaza Ciudad de los Cármenes, No. 4, Granada, Spain.
3Institute IBS Granada, Plaza Ciudad de los Cármenes, No. 4, Granada, Spain. arrabalp at ono.com.
4Biochemical Department, Santa Ana Hospital, Granada, Spain.
5Endocrinology Department, Granada University Hospital, Granada, Spain.
6Biochemical Department, Granada University Hospital, Granada, Spain.
7Medicine Department, Granada University, Granada, Spain.
8Surgery Department, Institute IBS Granada, Granada University, Granada, Spain.

PURPOSE:
The aim of this study is to analyse the percentage of hypovitaminosis D, as well as its relationship with the various parameters of calcium-phosphate metabolism.
METHODS:
A case control study was conducted on 366 patients, divided into two groups: Group 1: 127 non-stone-forming patients, and Group 2: 239 calcium stone forming. A study was performed on calcium-phosphate metabolism and urinary lithogenic factors. The percentage of vitamin D deficiency (25-OH-vitamin D levels <20 ng/ml) between the groups was analysed and compared. The SPSS 20.0 statistics program was used for the analysis, with a p ≤ .05 being considered significant.
RESULTS:
The mean age of Group 1 was 52.1 years compared to 49.6 years in Group 2, with no significant differences (p = .07). Vitamin D levels were lower in Group 2 compared to Group 1 (25.7 vs. 28.4 ng/ml, p = .02). A vitamin D deficiency was observed in 28 % of the Group 2 stone-forming patients versus 15.7 % in Group 1 (p = .009), with an odds ratio (OR) of 2.09 (95 % CI; 1.19-3.63). In the stone-forming patients with a vitamin D deficiency, the only difference observed was the higher levels of iPTH compared to those stone-formers with a normal vitamin D (56.9 vs. 45.5 pg/ml, respectively; p = .0001).
CONCLUSION:
Calcium stone-forming patients have lower mean levels of vitamin D and a higher percentage of hypovitaminosis D than in non-stone-forming patients. This was only related to increased iPTH levels, with urine calcium and other lithogenic parameters having no obvious effect.

PMID: 27093967

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