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Herpes virus and vitamin D - many studies

Vitamin D is not as good a vaccine at preventing Shingles,
but Vitamin D also fights 100+ other health problems, including many viruses
Vitamin D improves the vaccine effectivness
Topical Vitamin D appears to treat shingles
The virus protects itself by reducing Vitamin D Receptor by 8X

13 VitaminDWiki pages have HERPES or SHINGLES in the title (March 2023)

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Items found: 13

2.7 X more likely to have low Vitamin D if have Herpes Simplex Virus-2 - Nov 2022

The association between serum 25-hydroxyvitamin D and the prevalence of herpes simplex virus
J Med Virol . 2022 Nov 11. doi: 10.1002/jmv.2829
Jiaofeng Huang 1 2 , Yinlian Wu 1 2 , Mingfang Wang 1 2 , Su Lin 1 2

Objective: Previous studies have reported a potential anti-infection effect for vitamin D. However, the relationship between vitamin D status and herpes simplex virus (HSV) infection has not yet been evaluated. Therefore, this study aimed to determine the association between serum 25-hydroxyvitamin D [25(OH)D] and infection with HSV types 1 and 2 (HSV-1 and HSV-2).

Methods: Data were collected from the National Health and Nutrition Examination Survey (NHANES) from 2007-2016. The association between 25(OH)D and HSV prevalence was evaluated using propensity score matching (PSM) and univariate and multivariate logistic regression analyses.

Results: Overall, 14174 participants were included in the final analysis. Before PSM, 8639 (60.9%) had positive HSV-1 and 2636 (18.6%) had HSV-2. The HSV-1 and HSV-2 positive groups had more females and older individuals (P<0.05).

The HSV-2 patients had lower 25(OH)D levels than those with HSV-1. Age and gender did not differ in the groups after PSM (P>0.05).

The 25(OH)D level was significantly lower in the HSV-1 and HSV-2 groups than in the non-HSV infection groups. Multivariate logistic regression showed that serum 25(OH)D level was negatively associated with HSV-1 and HSV-2 infection (OR=0.730 and 0.691, P<0.001, respectively).
Vitamin D deficiency was an independent risk factor for both HSV-1 and HSV-2 (adjusted OR=2.205 and 2.704, P<0.001, respectively).

Conclusion: Lower serum 25(OH)D levels correlated significantly with increased HSV-1 and HSV-2 infection risk This article is protected by copyright. All rights reserved.

Herpesvirus and Vitamin D in immunosuppressed patients - inconclusive meta-analysis Jan 2021

Vitamin D Deficiency or Supplementation and the Risk of Human Herpesvirus Infections or Reactivation: A Systematic Review and Meta-analysis
Open Forum Infectious Diseases, Volume 8, Issue 1, January 2021, ofaa570,
Liang-Yu Lin, Ketaki Bhate, Harriet Forbes, Liam Smeeth, Charlotte Warren-Gash, Sinéad M Langan

Vitamin D may protect against respiratory virus infections, but any association with herpesviruses is unclear.
We undertook a systematic review of vitamin D deficiency or supplementation and the risk of 8 human herpesviruses. Six databases and 4 gray literature databases were searched for relevant cohort studies, case–control studies, and clinical trials.
Ten studies were included, all conducted among immunosuppressed patients. There was no evidence that vitamin D deficiency is associated with cytomegalovirus (CMV) disease (pooled risk ratio, 1.06; 95% CI, 0.66–1.7), herpes zoster after transplantation (1 study), or HHV-8 among HIV patients (1 study). Vitamin D supplementation may decrease herpes zoster among hemodialysis patients (1 study) or CMV disease after renal transplantation (1 study), but supplementation was not associated with reduced EBV viral load among multiple sclerosis patients (1 study).
Any association between vitamin D and herpesviruses remains inconclusive. Further studies in the general population are needed.
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2 doses of Zoster Vaccine provides protection against Shingles for more than 4 years - April 2024

Trial site News
Kaiser Study (behind paywall) Jan 2024

  • "Once an individual receives two doses VE equaled 79% during year one, 75% during year two and 73% during year three and four. "

Chinese in S. California with 2 doses of Zoster Vaccine had similar benefits for 4 years (a subset of Kaiser study?) - March 2024

Real-world effectiveness of recombinant zoster vaccine in self-identified Chinese individuals aged >50 years in the United States
HUMAN VACCINES & IMMUNOTHERAPEUTICS 2024, VOL. 20, NO. 1, 2327145 https://doi.org/10.1080/21645515.2024.2327145
Ana Florea a, Lina Sy a, Lei Qian a, Bradley Ackerson a, Yi Luo a, Jun Wu a, Yanjun Cheng a, Jennifer Ku a, Leticia Vega Daily@a, Harpreet Takhar@a, Jeannie Song a, Elizabeth Chmielewski-Yee©b, O'Mareen Spence©b, Harry Seifert c, Driss Oraichi d, and Hung Fu Tseng a,e
aDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA; bDepartment of Epidemiology and Patient- Centered Outcomes, GSK, Rockville, MD, USA; department of Clinical Safety and Pharmacovigilance, GSK, Rockville, MD, USA; department of Real World Analytics, GSK, Rockville, MD, USA; department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA


We evaluated the vaccine effectiveness (VE) of two doses of recombinant zoster vaccine (RZV) against herpes zoster (HZ) and postherpetic neuralgia (PHN) in Chinese adults at Kaiser Permanente Southern California (KPSC). Chinese KPSC members were identified based on self-reported ethnicity or self- reported preferred spoken/written language. Those aged >50 years who received two doses of RZV 4 weeks to < 6 months apart were matched 1:4 to RZV unvaccinated Chinese members and followed through June 2022; second doses were accrued 6/1/2018-12/31/2020. We estimated incidence and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) comparing outcomes (HZ and PHN). Adjusted VE (%) was calculated as (1-aHR)x100. 3978 RZV vaccinated Chinese members were matched to 15,912 RZV unvaccinated Chinese members. The incidence per 1000 person-years (95% CI) of HZ in the vaccinated group was 1.5 (0.9-2.5) and 10.9 (9.8-12.1) in the unvaccinated group; aHR (95% CI) was 0.12 (0.07-0.21). Adjusted VE (95% CI) was 87.6% (78.9-92.7) against HZ. We identified 0 PHN cases in the vaccinated group and 19 in the unvaccinated group. Among Chinese adults aged >50 years, two doses of RZV provided substantial protection against HZ and PHN supporting the real-world effectiveness of the vaccine in this population.
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Cold Sores (herpes labialis) occur more often in winter is associated with low levels of vitamin D - 2019

Vitamin D Levels in Patients with Recurrent Herpes Labialis
Viral Immunol . 2019 Jul/Aug;32(6):258-262. doi: 10.1089/vim.2019.0013
Aynure Öztekin 1, Coşkun Öztekin 2

Recurrent infections of herpes simplex virus in the orolabial area are known as recurrent herpes labialis (RHL). Vitamin D has been shown to have an important immunomodulatory role and to be associated with several infectious diseases. This hospital-based case-control study aimed at investigating the association between vitamin D and RHL by comparing vitamin D levels in individuals with and without RHL. Individuals who presented to the dermatology clinic at a state hospital due to RHL (n = 50) and matching control group of healthy volunteers (n = 51) were studied. Their vitamin D levels were measured, stratified based on clinical guidelines, and compared. The average serum vitamin D (25-hydroxyvitamin D) levels were 23.8 ± 15.5 and 42.0 ± 26.3 nM in the patient and control groups, with significant differences between their average serum vitamin D levels and vitamin D status. The studied population had serious vitamin D deficiency regardless of having RHL, with vitamin D levels below the adequate limits in more than 96% of the population. Most importantly, the study established a significant association between low serum vitamin D levels and the presence of RHL. Further interventional and pathophysiological studies should clarify the nature and mechanism of the relationship.
 Download the PDF from Sci-Hub via VitaminDWiki

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Herpes virus and vitamin D - many studies        
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ID Name Comment Uploaded Size Downloads
21133 Zoster Chinese.webp admin 26 Apr, 2024 12.83 Kb 64
21132 Chinese shingles.webp admin 26 Apr, 2024 18.10 Kb 66
21131 Real-world_effectiveness_of_recombinant_zoster_vac_CompressPdf.pdf admin 26 Apr, 2024 416.52 Kb 53
19488 Herpes Labialis.pdf admin 21 Apr, 2023 127.69 Kb 191
18806 Herpes Jan 2021.pdf admin 14 Nov, 2022 301.53 Kb 232