J Wound Care. 2021 Jun 1;30(Sup6):S4-S10. doi: 10.12968/jowc.2021.30.Sup6.S4.
Karen Smith 1, Susan Hewlings 1
Wound healing often needs some combination of:
Vitamin D - (nanoemulsion works very well)
Vitamin D - non-daily
Resveratrol or something to improve the vitamin D receptor
This review appears to only consider daily oral Vitamin D mono-therapy
- Skin and oral wounds treated via Vitamin D Receptor and Calcium (book chapter) – Feb 2018
- Burn patients have little vitamin D and benefit when it is restored
- Severely burned children recovered muscle capability much faster with daily 1000 IU of vitamin D – RCT March 2017
- Treat wounds, stop inflammation with nanoemulsion textile of Omega-3 and Resveratrol - Sept 2019
- Wound dressing will have Vitamin D - should reduce infections - July 2018
- Wounds and burns healed with Vitamin D
- Venous ulcers healed 4X faster with weekly 50000 IU vitamin D – RCT Oct 2012
Objective: Hard-to-heal wounds are a major biological, psychological, social and financial burden on both individual patients and the broader health system. They are associated with a variety of comorbidities and have a complex aetiology, but are typically associated with nutritional deficiencies, such as low vitamin D levels. This systematic literature review evaluates the current research regarding the connection between inadequate vitamin D status and wound healing.
Method: PubMed and EBSCO databases were searched following PRISMA guidelines for primary research studies relating to pressure ulcers, diabetic ulcers or venous ulcers and vitamin D status.
Results: A total of 10 studies, involving 2359 participants, met the inclusion criteria. There was a strong correlation between low levels of 25-hydroxyvitamin D and the presence of all three types of hard-to-heal wounds.
Conclusion: Research suggests a correlation between low vitamin D levels and hard-to-heal wounds. However, it is not clear if the relationship is causal or only correlational. There is also emerging evidence on the use of vitamin D supplementation for the treatment of hard-to-heal wounds. More research is needed to understand the correlation between vitamin D and hard-to-heal wounds.
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