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Hard-to-heal Wounds associated with low vitamin D – review June 2021

Correlation between vitamin D levels and hard-to-heal wounds: a systematic review

J Wound Care. 2021 Jun 1;30(Sup6):S4-S10. doi: 10.12968/jowc.2021.30.Sup6.S4.
Karen Smith 1, Susan Hewlings 1


Objective: Hard-to-heal wounds are a major biological, psychological, social and financial burden on both individual patients and the broader health system. They are associated with a variety of comorbidities and have a complex aetiology, but are typically associated with nutritional deficiencies, such as low vitamin D levels. This systematic literature review evaluates the current research regarding the connection between inadequate vitamin D status and wound healing.

Method: PubMed and EBSCO databases were searched following PRISMA guidelines for primary research studies relating to pressure ulcers, diabetic ulcers or venous ulcers and vitamin D status.

Results: A total of 10 studies, involving 2359 participants, met the inclusion criteria. There was a strong correlation between low levels of 25-hydroxyvitamin D and the presence of all three types of hard-to-heal wounds.

Conclusion: Research suggests a correlation between low vitamin D levels and hard-to-heal wounds. However, it is not clear if the relationship is causal or only correlational. There is also emerging evidence on the use of vitamin D supplementation for the treatment of hard-to-heal wounds. More research is needed to understand the correlation between vitamin D and hard-to-heal wounds.

References

  • The dysvascular foot: a system for diagnosis and treatment -Sep 1, 1981·Foot & Ankle·F W Wagner
  • Prevalence and correlates of vitamin D deficiency in US adults -Feb 12, 2011·Nutrition Research·Kimberly Y Z Forrest, Wendy L Stuhldreher
  • Serum 25-hydroxyvitamin D is a reliable indicator of vitamin D status -Jul 22, 2011·The American Journal of Clinical Nutrition·Robert P Heaney
  • Management of diabetic foot ulcers.– Apr 25, 2012·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kleopatra Alexiadou, John Doupis
  • Prevalence and severity of vitamin D deficiency in patients with diabetic foot infection– Jun 22, 2012·The British Journal of Nutrition·Shalbha TiwariSurya Kumar Singh
  • Vitamin D and skin repair: a prospective, double-blind and placebo controlled study in the healing of leg ulcers -Nov 24, 2012·Revista do Colégio Brasileiro de Cirurgiões·Claudine Juliana Cristina Caznoch BurkiewiczGleim Dias De Souza
  • 25-Hydroxyvitamin D [25(OH)D] levels and diabetic foot ulcer: is there any relationship? -Aug 21, 2013·Diabetes & Metabolic Syndrome·Mohammad ZubairJamal Ahmad
  • Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection -Oct 22, 2014·The British Journal of Nutrition·Shalbha TiwariSurya Kumar Singh
  • Vitamin D and calcium regulation of epidermal wound healing -Aug 19, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Yuko OdaDaniel D Bikle
  • Vitamin D and the skin: Focus on a complex relationship: A review -Dec 9, 2015·Journal of Advanced Research·Wedad Z Mostafa, Rehab A Hegazy
  • Raised serum 25-hydroxyvitamin D levels in patients with active diabetic foot ulcers -May 7, 2016·The British Journal of Nutrition·Mohsen AfaridehAlireza Esteghamati
  • The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial =Jul 2, 2016·Journal of Diabetes and Its Complications·Reza RazzaghiZatollah Asemi
  • Revised National Pressure Ulcer Advisory Panel Pressure Injury Staging System: Revised Pressure Injury Staging System =Oct 18, 2016·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Laura E EdsbergMary Sieggreen
  • The quality of life of people who have chronic wounds and who self-treat -May 12, 2017·Journal of Clinical Nursing·Suzanne KappNick Santamaria
  • Nutritional blood parameters and nutritional risk screening in patients with spinal cord injury and deep pressure ulcer-a retrospective chart analysis – Oct 24, 2017·Spinal Cord·Cristina LussiAnke Scheel-Sailer
  • An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds – Jan 7, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Samuel R NussbaumDonna Cartwright
  • Pressure Ulcer and Nutrition – May 11, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Seied Hadi SaghaleiniZohreh Ostadi
  • Severe Vitamin D3 Deficiency in the Majority of Patients with Diabetic Foot Ulcers – Jul 6, 2018·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Joachim FeldkampMichael Roden
  • Vitamin D Status Is Associated With Development of Hospital-Acquired Pressure Injuries in Critically Ill Surgical Patients -Aug 14, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Tiffany M N OteroSadeq A Quraishi
  • Osteoprotegerin and 25-hydroxy vitamin D levels in patients with diabetic foot – Nov 1, 2018·Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery·Sever ÇağlarHakan Sarı



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