Clin Ther. 2022 Apr 12;S0149-2918(22)00136-9. doi: 10.1016/j.clinthera.2022.03.012
Zsuzsanna Putz 1, Dóra Tordai 2, Noémi Hajdú 2, Orsolya Erzsébet Vági 2, Miklós Kempler 3, Magdolna Békeffy 2, Anna Erzsébet Körei 2, Ildikó Istenes 2, Viktor Horváth 2, Anca Pantea Stoian 4, Manfredi Rizzo 5, Nikolaos Papanas 6, Péter Kempler 2
Purpose: Neuropathy is one of the most important complications of diabetes. According to recent advances, vitamin D deficiency might play a role in the development and progression of diabetic neuropathy. Moreover, therapeutic vitamin D supplementation has the potential to improve this condition. The aim of the present review was to summarize new data available in this area.
Methods: The PubMed database was searched for articles written in English and published through September 2021, using combinations of the following key words: vitamin D, diabetes, diabetes mellitus, diabetic neuropathy, polyneuropathy, peripheral neuropathy, cardiac autonomic neuropathy, supplementation, and therapy.
Findings: A number of studies have suggested that vitamin D deficiency can play a significant role in the development of peripheral neuropathy, diabetic foot ulcers, as well as cardiovascular autonomic neuropathy in patients with type 2 diabetes. Vitamin D supplementation might serve as an effective adjuvant therapy for neuropathic pain and may slow or stop the progression of neural damage.
Implications: Vitamin D therapy for diabetic complications could be a reliable option; however, further studies are needed to confirm this notion.
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