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Dengue virus infection treated by (active) Vitamin D in the lab – April 2012

The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes.

Antiviral Res. 2012 Apr;94(1):57-61. doi: 10.1016/j.antiviral.2012.02.006. Epub 2012 Feb 22.
Puerta-Guardo H1, Medina F, De la Cruz Hernandez SI, Rosales VH, Ludert JE, del Angel RM.rmangel at cinvestav.mx

Dengue is the most important mosquito-borne viral infection in humans. Recent evidence suggests that vitamin D influences virus replication. In this work, the effect of vitamin D treatment on dengue virus infection in human hepatic Huh-7 cells and on virus infection and cytokine production in the human monocytic U937 cells was evaluated. Exposure to 1α,25-dihydroxy-vitamin D3, resulted in a significant reduction in the number of infected cells, in conditions where cell viability was not affected. Viral replication in monocytic cells was more susceptible to vitamin D3 than replication in the hepatic cells. Moreover, vitamin D3 significantly reduced the levels of proinflammatory cytokines (TNF-α, IL-6, IL-12p70 and IL-1β) produced by infected U937 cells.
These results suggest that vitamin D3 may represent a potentially useful antiviral compound.

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Note by VitaminDWiki:
Active vitamin D must be used in the lab, as the lab has no liver and kidney to activate regular vitamin D

Papers which have referenced this paper as of May 2015 via Google Scholar

Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages
M Di Rosa, G Malaguarnera, C De Gregorio… - Cellular …, 2012 - Elsevier
Vitamin D3 [1α, 25-(OH) 2D3], involved in the regulation of body calcium homeostasis,
promotes immature myeloid precursor cells differentiation into monocytes/macrophages. In
this study we compared the regulatory interaction between 1α, 25-(OH) 2D3 and tumor ...

Vitamin D: a new anti‐infective agent?
E Borella, G Nesher, E Israeli… - Annals of the New York …, 2014 - Wiley Online Library
Before the antibiotic era, treatment of tuberculosis patients was restricted to sun exposure in
sanatoria. Years later, it was found that 1, 25-dihydroxyvitamin D3 stimulates production of
cathelicidins, a family of polypeptides found in lysosomes of macrophages and ...

Micronutrients and dengue
S Ahmed, JL Finkelstein, AM Stewart, J Kenneth… - The American journal of …, 2014 - ASTMH
Abstract. Dengue virus infection is the most widespread mosquito-borne viral infection in
humans and has emerged as a serious global health challenge. In the absence of effective
treatment and vaccine, host factors including nutritional status, which may alter disease ...
 Download the PDF from VitaminDWiki

Dietary diallyl disulfide supplementation attenuates ethanol-mediated pulmonary vitamin D speciate depletion in C57Bl/6 mice
ML McCaskill, HT Hottor, M Sapkota, TA Wyatt - BMC Nutrition, 2015 - biomedcentral.com
Background Slightly more than 5% of the United States population heavily consumes
ethanol, ie, more than 14 drinks for men and 7 drinks for women a week. Chronic ethanol
consumption can result in increased liver disease, reduced recovery from burn injury, and ...

Vitamin D-Regulated MicroRNAs: Are They Protective Factors against Dengue Virus Infection?
JF Arboleda, S Urcuqui-Inchima - Advances in Virology, 2016 - hindawi.com
Over the last few years, an increasing body of evidence has highlighted the critical
participation of vitamin D in the regulation of proinflammatory responses and protection
against many infectious pathogens, including viruses. The activity of vitamin D is ...
   on VitaminDWiki

Review of Current Dengue Treatment and Therapeutics in Development
DN Fusco, RT Chung - Journal of Bioanalysis & Biomedicine, 2014 - omicsonline.org
Dengue is an arthropod-borne flavivirus associated with hemorrhagic fever and
hemorrhagic shock. Roughly one third of the world population lives at risk of dengue
infection, and it is not possible to accurately predict which patients are at risk for severe or ...

Caracterização dos efeitos imunomodulador e antiviral de uma espécie da família marcgraviaceae em modelo in vitro de infecção em linhagem de hepatócitos HUH- …
LG Fialho - 2015 - arca.fiocruz.br
Várias doenças relacionadas à desregulação do sistema imunológico têm sido, há muito
tempo, tratadas com a medicina fitoterápica, considerando que vários efeitos terapêuticos
podem ser induzidos pela modulação de citocinas. Entretanto, não são encontrados ...

Attached files

ID Name Comment Uploaded Size Downloads
6686 Micronutrients and Dengue.pdf admin 20 May, 2016 493.01 Kb 665
6685 The 1a,25-dihydroxy-vitamin D3 reduces dengue virus infection in human.pdf admin 20 May, 2016 534.46 Kb 862