Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome.
Epidemiol Infect. 2017 Sep 14:1-10. doi: 10.1017/S0950268817002059. [Epub ahead of print]
Villamor E1, Villar LA2, Lozano A2, Herrera VM2, Herrán OF2.
- 1 Department of Epidemiology,University of Michigan School of Public Health,Ann Arbor,MI,USA.
- 2 Faculty of Health,Centre for Epidemiological Investigations,Industrial University of Santander,Bucaramanga,Colombia.
Poor Dengue Fever outcome vs > 30 ng
|Vitamin D||Increased Risk|
|20-30 ng||2.3 X|
|< 20 ng||8 X|
- Dengue Fever associated with poor vitamin D receptor – July 2002
Poor receptor also lowers the vitamin D which gets to the cells
- Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015
- Dengue virus infection treated by (active) Vitamin D in the lab – April 2012
- Dengue virus avoids the INNATE immune system – Dec 2012
- Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis, Ebola) – March 2011
Note: Dengue is another enveloped virus
- All items in category Virus
Vitamin D could modulate pathways leading to dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We examined the associations of serum total 25-hydroxy vitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations in patients with uncomplicated dengue fever (DF) with risk of progression to DHF/DSS. In a case-control study nested in a cohort of DF patients who were followed during the acute episode in Bucaramanga, Colombia, we compared 25(OH)D and VDBP at onset of fever between 110 cases who progressed to DHF/DSS and 235 DF controls who did not progress. 25(OH)D concentrations were also compared between the acute sample and a sample collected >1 year post-convalescence in a subgroup. Compared with 25(OH)D ⩾75 nmol/l, adjusted odds ratios (95% CI) for progression were 0·44 (0·22-0·88) and 0·13 (0·02-1·05) for 50 to 75 nmol/l (vitamin D insufficiency) and <50 nmol/l (vitamin D deficiency), respectively (P, trend = 0·003). Mean 25(OH)D concentrations were much lower post-convalescence compared with the acute episode, regardless of case status. Compared with controls, mean VDBP was non-significantly lower in cases. We conclude that low serum 25(OH)D concentrations in DF patients predict decreased odds of progression to DHF/DSS.
PMID: 28903788 DOI: 10.1017/S0950268817002059