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50,000 IU of Vitamin D weekly for 9 weeks did not improve CVD – Aug 2018

High-dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow-up study.

Ann Clin Biochem. 2018 Mar;55(2):227-235. doi: 10.1177/0004563217707784. Epub 2017 Sep 6.
Khayyatzadeh SS1, Mirmoosavi SJ2, Fazeli M3, Abasalti Z1, Avan A3, Javandoost A1, Rahmani F1, Tayefi M3, Hanachi P4, Ferns GA5, Bahrami-Taghanaki H6, Ghayour-Mobarhan M1,3.

  • Cardio parameters would havestatistically signficantly improved if they had extended the trial: to say 18+ weeks
  • Personal note: I have been taking 50,000 IU every 4 or 5 days for over 6 years
    H Lahore, founder of VitaminDWiki

Overview Loading of vitamin D contains the following

Loading dose: 194 studies at VitaminDWiki

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

  • Loading = restore = quick replacement by 1 or more doses
  • Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
    • = 2.5 to 25 milligrams
  • The size of the loading dose is a function of body weight - see below
    • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
    • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
  • Loading is typically oral, but can be Injection (I.M,) and Topical
  • Loading dose is ~3X faster if done topically or swished inside of the mouth
    • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
  • The loading dose persists in the body for 1 - 3 months
    • The loading dose should be followed up with on-going maintenance dosing
    • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
    • it appears prudent to test with a small amount of vitamin D before giving a loading dose
    • The causes of a mild allergic reaction appear to be: (in order of occurrence)
    • 1) lack of magnesium - which can be easily added
    • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
    • 4) allergy of the gut to Vitamin D - alternative = topical

 Download the PDF from VitaminDWiki


Background Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here, we explored the effects of high-dose vitamin D supplementation on cardio-metabolic risk factors.

Methods We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurements were obtained at baseline and after supplementation with high-dose vitamin D. All individuals took a capsule of 50,000 IU vitamin D/week for nine weeks. The study was completed by 940 participants.

Results The prevalence of vitamin D deficiency was 90% at baseline, reducing to 16.3% after vitamin D supplementation. Vitamin supplementation was associated with a significant increase in serum concentrations of 25 (OH) vitamin D and calcium. There were significant reductions in diastolic blood pressure, heart rate, waist circumference and serum fasting blood glucose, total- and low-density lipoprotein-cholesterol after the nine-week period on vitamin D treatment, but no significant effects were observed on body mass index, systolic blood pressure or serum high-density lipoprotein cholesterol and triglyceride.

Conclusion Vitamin D supplementation had beneficial effects on cardio-metabolic profile in adolescent girls.

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Created by admin. Last Modification: Tuesday December 22, 2020 17:33:30 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
14758 9 weeks 50,000.jpg admin 22 Dec, 2020 17:32 37.62 Kb 240
10431 cardio-metabolic risk factors 50,000 IU 9 weeks.pdf PDF 2018 admin 28 Aug, 2018 15:23 899.36 Kb 692