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150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012

Vitamin D Supplementation for Nonspecific Musculoskeletal Pain in Non-Western Immigrants:
A Randomized Controlled Trial

Ann Fam Med November/December 2012 vol. 10 no. 6 547-555
Ferdinand Schreuder , and colleagues

Background
Many non-Western immigrants suffer musculoskeletal pain that is hard to treat.
This study examines the effect of high-dose vitamin D on nonspecific persistent musculoskeletal complaints in vitamin-D-deficient non-Western immigrants.

What This Study Found
High-dose vitamin D supplementation may have a positive effect on persistent musculoskeletal pain among vitamin D-deficient patients. A study of 84 non-Western immigrants in Western Europe, a population prone to vitamin D deficiency and musculoskeletal problems, revealed a small positive effect on pain 6 weeks after supplementation with 150,000 IU of Vitamin D3 on vitamin D-deficient patients.

Specifically, patients randomized to receive vitamin D supplementation were significantly more likely than those in a control group to report pain relief 6 weeks after treatment (35% vs 20%). The former were also more likely to report an improved ability to walk stairs (21%t vs 8%). In a nonsignificant trend, patients receiving vitamin D over 12 weeks were more likely to have an improvement than patients receiving it over 6 weeks.

Implications
The authors call for future investigation involving greater numbers of participants with longer follow-up and higher doses.
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PDF is attached at the bottom of this page
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Summary by VitaminDWki

  • Single 150,000 IU dose to group which is typically very vitamin D deficient, then check 6 weeks later
  • Pain relief reported 35% vs 20% of the control group
  • Impoved ability to walk stairs 21% vs 8% in the control group

Comment by VitaminDWiki

A larger dose could have been given (say 200,000 IU), and the dose could have given every two weeks
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Attached files

ID Name Comment Uploaded Size Downloads
4370 Schreuder.jpg admin 17 Sep, 2014 98.81 Kb 1447
2703 Pain.jpg admin 02 Jul, 2013 42.48 Kb 1505
2702 Pain RCT.pdf admin 02 Jul, 2013 182.62 Kb 1033