Nonspecific pain is a marker for hypovitaminosis D in patients undergoing evaluation for sleep disorders: a pilot study
Published Date March 2013 Volume 2013:5 Pages 37 - 42, DOI: http://dx.doi.org/10.2147/NSS.S42641
David E McCarty,1 Aronkumar Reddy,1 Quinton Keigley,2 Paul Y Kim,1 Stephen Cohen,2 Andrew A Marino1
1 Division of Sleep Medicine, Department of Neurology, Louisiana State University Health Sciences Center,
2 School of Medicine, Louisiana State University, Shreveport, LA, USA
Background: The purpose of this cross-sectional study was to test the hypothesis that serum vitamin D levels are abnormally low in sleep clinic patients admitting to chronic nonspecific musculoskeletal pain and to assess the associated risk factors. A secondary purpose was to identify a clinical biomarker for vitamin D deficiency.
Methods: We enrolled 153 consecutive patients who admitted to the presence of chronic nonspecific musculoskeletal pain during a comprehensive sleep evaluation at a specialist sleep medicine clinic within an academic center. Venous blood sampling was performed for determination of serum 25-hydroxyvitamin D. Risk factors for vitamin D deficiency (25-hydroxyvitamin D < 20 ng/mL) were identified by odds ratios. Receiver-operating characteristic curve analysis was performed with 10-fold cross-validation to identify a biomarker for vitamin D deficiency calculated by linear discriminant analysis.
Results: The mean serum 25-hydroxyvitamin D level was 19.8 ± 11.1, with 54% of the study population having vitamin D deficiency. This mean 25-hydroxyvitamin D level was lower than that observed historically in healthy controls, and was either similar or lower than in all but one representative historical cohort formed on the basis of chronic nonspecific musculoskeletal pain. Risk factors for vitamin D deficiency were black ethnicity, age < 60 years, and obesity. These risk factors were identified both in the entire cohort and separately in subgroups with and without obstructive sleep apnea. The biomarker (based on race, age, and body mass index) had a sensitivity and specificity for predicting vitamin D deficiency of 0.73 and 0.74, respectively.
Conclusion: Vitamin D deficiency was prevalent in patients with sleep disorders and chronic nonspecific musculoskeletal pain on evaluation in a sleep medicine clinic. Vitamin D deficiency was reliably estimated in the study population using a biomarker derived from common demographic characteristics.
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- Overview Pain and Vitamin D
- Overview Dark Skin and Vitamin D
Items in both categories Sleep and Skin-dark are listed here:
Items in both categories Pain-chronic and Skin-dark are listed here:
- Pain following auto accident is worse if low vitamin D (for African Americans) – April 2015
- Dark skinned in Norway: 1000 IU vitamin D not enough to reduce pain – RCT Sept 2014
- Most immigrant women in Sweden had little vitamin D and lots of muscle pain – May 2013
- Sleep disorder and nonspecific pain implies low vitamin D, especially if dark skin – March 2013
- 150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012
- Blacks had lower vitamin D and more quantifiable pain than whites with knee osteoarthritis – Nov 2012