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Vitamin D deficiency in both parents associated with 41 X higher risk of deficient adolescents – April 2018

Familial clustering of vitamin D deficiency via shared environment: The Korean National Health and Nutrition Examination Survey 2008–2012

European Journal of Clinical Nutrition (2018), onlinec18 April 2018, doi:10.1038/s41430-018-0157-3
Namki Hong, Young Ki Lee & Yumie Rhee


Many reasons for the strong association include:

Shared skin color
Tendancy to be indoors a lot
Tendancy to not eat fatty fish
Tendancy to smoke
Tendancy to not supplement with vitamin D
Tendancy to be overweight
Shared genes
Low Magnesium in drinking water
Plastics in blood
DDT / pesticides in blood
Glysophate in blood
Share a health problem which consumes Vit. D (i.e. Diabetes)

Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or parent-offspring studies. However, data on relative contribution of environmental factors on familial clustering of 25(OH)D in extended families are limited.

We performed cross-sectional study using data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2012. Familial correlations of 25(OH)D were estimated in 28,551 subjects from 10,882 families. The variance component method was used to assess the relative contribution of additive genetic or environmental contributions to the variation in 25(OH)D level. Logistic regression models with interaction term were built to evaluate the differential influence of parental vitamin D status on the adolescents and adults offspring.

Mean serum 25(OH)D concentration of subjects was 44.6 nmol/L (vitamin D insufficiency (30–50 nmol/L), 51%; vitamin D deficiency ( < 30 nmol/L), 17%). Familial clustering explained 40% of the total variation in 25(OH)D. In the variance component model, 4%, 39%, and 57% of the variation in serum 25(OH)D level was attributed to additive genetic, common shared environmental, and individual environmental factors, respectively. The odds of vitamin D deficiency in offspring with both parents with vitamin D deficiency compared with those with both parents with sufficient vitamin D levels was greater in adolescents ( < 19 years) than in adults ( ≥ 19 years) (odds ratio = 41.1 vs. 12.5; p for interaction = 0.03).

We found a familial clustering of vitamin D deficiency in a large family-based cohort. Parental influence on vitamin D status of offspring was greater in adolescents than in adults.

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