Immunol Allergy Clin North Am 30(3):397-409 (2010)
profile Daniel A Searing and profile Donald Y M Leung
Division of Pediatric Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, K731a, Denver, CO 80206, USA.
This review examines the scientific evidence behind the hypothesis that vitamin D plays a role in the pathogenesis of allergic diseases, along with a focus on emerging data regarding vitamin D and atopic dermatitis. Elucidated molecular interactions of vitamin D with components of the immune system and clinical data regarding vitamin D deficiency and atopic diseases are discussed.
The rationale behind the sunshine hypothesis, laboratory evidence supporting links between vitamin D deficiency and allergic diseases, the clinical evidence for and against vitamin D playing a role in allergic diseases, and the emerging evidence regarding the potential use of vitamin D to augment the innate immune response in atopic dermatitis are reviewed. Copyright © 2010 Elsevier Inc. All rights reserved. DOI: 10.1016/j.iac.2010.05.005 * PMID: 20670821