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Vitamin D from mushroom or supplements decreased vitamin D3 in the body – June 2012

Ergocalciferol from Mushrooms or Supplements Consumed with a Standard Meal

Increases 25-Hydroxyergocalciferol

but Decreases 25-Hydroxycholecalciferol in the Serum of Healthy Adults1,2,3

J. Nutr. July 1, 2012 vol. 142 no. 7 1246-1252
Manuscript received: Feb 14, 2012; Initial review completed: Feb 23, 2012; Revision accepted: April 10, 2012.
Charles B. Stephensen 4,5,*, Melissa Zerofsky 4,5, Dustin J. Burnett 4,5, Yan-ping Lin 6, Bruce D. Hammock 6, Laura M. Hall 7, and Tara McHugh 8
4 USDA-Agricultural Research Service Western Human Nutrition Research Center
5 Nutrition Department, and
6 Department of Entomology, University of California, Davis, CA
7 Food Science and Nutrition Department, California Polytechnic State University, San Luis Obispo, CA; and
8 USDA-Agricultural Research Service Western Regional Research Center, Processed Foods Research Unit, Albany, CA
?*To whom correspondence should be addressed. E-mail: charles.stephensen at ars.usda.gov.

Few foods contain ergocalciferol or cholecalciferol. Treatment of mushrooms with UV light increases ergocalciferol content and could provide a dietary source of vitamin D. We evaluated the impact of consuming UV-treated white button mushrooms (Agaricus bisporus) on the vitamin D status of healthy adults.
Thirty-eight volunteers were randomized to 4 treatments consumed with a standard meal for 6 wk: the

  • control (C) group received untreated mushrooms providing 0.85 ?g/d ergocalciferol (n = 10); *groups M1 and M2 received UV-treated mushrooms providing 8.8 (n = 10) and 17.1 ?g/d (n = 9), respectively; and the
  • supplement (S) group received purified ergocalciferol plus untreated mushrooms, providing a total of 28.2 ?g/d (n = 9).

Serum total 25-hydroxyvitamin D [25(OH)D] and 25-hydroxyergocalciferol [25(OH)D2] were 83 ± 38 and 2.4 ± 2.0 nmol/L, respectively, at baseline (mean ± SD).
At week 6, 25(OH)D2 had increased and was higher in all treatment groups than in the C group, whereas 25-hydroxycholecalciferol [25(OH)D3] had decreased and was lower in the M2 and S groups than in the C group.
Increases in 25(OH)D2 for groups C, M1, M2, and S were 1.2 ± 5.2, 13.8 ± 7.3, 12.7 ± 3.7, and 32.8 ± 3.3 nmol/L and
decreases in 25(OH)D3 were ?3.9 ± 16.3, ?10.4 ± 6.4, ?20.6 ± 14.6, and ?29.5 ± 15.9 nmol/L, respectively. Concentrations did not change in group C.

In summary, ergocalciferol was absorbed and metabolized to 25(OH)D2 but did not affect vitamin D status, because 25(OH)D3 decreased proportionally.

Footnotes

?2 Author disclosures: C. B. Stephensen and T. McHugh received research funding from The Mushroom Council. M. Zerofsky, D. J. Burnett, Y-p., Lin, B. D. Hammock, and L. M. Hall, no conflicts of interest.
?1 Supported by The Mushroom Council (research grant to C.B.S.) and by USDA, Agricultural Research Service project no. 5306-51530-018-00. The USDA is an equal opportunity provider and employer. Mushrooms were provided by Monterey Mushroom, Inc.
?3 Supplemental Table 1 and Figures 1–3 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at http://jn.nutrition.org.
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Summary by VitaminDWiki – after 6 weeks

IU of D2ng of D3
34 IU – 1.6 ng
352 IU -4.2 ng
684 IU -8.2 ng
1128 IU -12 ng

Comment by VitaminDWiki - Probably not the result which the Mushroom Council expected when they funded this study
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See also VitaminDWiki

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