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Prediabetes progression to diabetes 25 percent less for every 4 ng increase in vitamin D – April 2012

Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance

Diabetologia. European Association for the Study of Diabetes
A. Deleskog, A. Hilding, K. Brismar, A. Hamsten, S. Efendic and C.-G. Östenson

Aims/hypothesis
Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D.

Methods
At baseline, participants aged 35–56 years without known type 2 diabetes were examined using OGTTs, 25(OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8–10 years later were selected as cases; these were then age- and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men.

Results
Men but not women in the highest quartile of 25(OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline.

In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D.

A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men.

Conclusions/interpretation
High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in t!erms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.
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See also VitaminDWiki

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References

  • Mathieu C, Gysemans C, Giulietti A, Bouillon R (2005) Vitamin D and diabetes. Diabetologia 48:1247–1257
  • Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029
  • Holick MF (2007) Vitamin D deficiency. New Engl J Med 357:266–281
  • Scragg R (2008) Vitamin D and type 2 diabetes. Are we ready for a prevention trial? Diabetes 57:2565–2566
  • Holick MF (2008) Diabetes and the vitamin D connection. Curr Diabetes Rep 8:393–398
  • Boucher JB (2011) Vitamin D insufficiency and diabetes risks. Current Drug Targets 12:61–87
  • Mattila C, Knekt P, Maennistoe S et al (2007) Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 30:2569–2570
  • Knekt P, Laaksonen M, Mattila C et al (2008) Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology 19:666–671
  • Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ (2008) Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance—the Medical Research Council Ely Prospective Study 1990–2000. Diabetes 57:2619–2625
  • Pittas AG, Sun Q, Manson JE, Dawson-Hughes B, Hu FB (2010) Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care 33:2021–2023
  • Liu E, Meigs JB, Pittas AG et al (2010) Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. Am J Clin Nutr 91:1627–1633
  • Gagnon C, Lu ZX, Magliano DJ et al (2011) Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years. Diabetes Care 34:1133–1138
  • Teegarden D, Donkin SS (2009) Vitamin D: emerging new roles in insulin sensitivity. Nutrition Res Rev 22:82–92
  • Alvarez JA, Ashraf A (2010) Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol 2010:351385. doi:
  • Kayaniyil S, Vieth R, Retnakaran R et al (2010) Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 33:1379–1381
  • Mitri J, Dawson-Hughes B, Hu FB, Pittas AG (2011) Effects of vitamin D and calcium supplementation on pancreatic ? cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr 94:486–494

Lewitt MS, Hilding A, Ostenson CG, Efendic S, Brismar K, Hall K (2008) Insulin-like growth factor-binding protein-1 in the prediction and development of type 2 diabetes in middle-aged Swedish men. Diabetologia 51:1135–1145
Lewitt MS, Hilding A, Brismar K, Efendic S, Ostenson CG, Hall K (2010) IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women. Eur J Endocrinol 163:233–242
Hypponen E, Boucher BJ, Berry DJ, Power C (2008) 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age. A cross-sectional study in the 1958 British birth cohort. Diabetes 57:298–305
Eriksson AK, Ekbom A, Granath F, Hilding A, Efendic S, Ostenson CG (2008) Psychological distress and risk of prediabetes and type 2 diabetes in a prospective study of Swedish middle-aged men and women. Diabetic Med 25:834–842
American Diabetes Association (2004) Diagnosis and classification of diabetes mellitus. Diabetes Care 27:S5–S10
Shankar A, Sabanayagam C, Kalidindi S (2011) Serum 25-hydroxyvitamin D levels and prediabetes among subjects free of diabetes. Diabetes Care 34:1114–1119
Barengolts E (2010) Vitamin D role and use in prediabetes. Endocrine Pract 16:476–485
Baz-Hecht M, Goldfine AB (2010) The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr Opin Endocrinol Diabetes Obes 17:113–119
Zittermann A (2003) Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 89:552–572
Davidson HW, Rhodes CJ, Hutton JC (1988) Intraorganellar calcium and pH control proinsulin cleavage in the pancreas beta cell via two distinct site-specific endopeptidases. Nature 333:93–96
Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S (1985) Evidence for alteration of the vitamin-D-endocrine system in obese subjects. J Clin Invest 76:370–373
Liel Y, Ulmer E, Shary J, Hollis BW, Bell NH (1988) Low circulating vitamin-D in obesity. Calcified Tissue Int 43:199–201
Macdonald HM, Mavroeidi A, Barr RJ, Black AJ, Fraser WD, Reid DM (2008) Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D. Bone 42:996–1003
Grimnes G, Emaus N, Joakimsen RM et al (2010) Baseline serum 25-hydroxyvitamin D concentrations in the Tromso Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow-up. Diabet Med 27:1107–1115
Schernhammer ES, Hankinson SE, Hunter DJ, Blouin MJ, Pollak MN (2003) Polymorphic variation at the ?202 locus in IGFBP3: influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk. Int J Cancer 107:60–64
Gomez JM, Maravall FJ, Gomez N, Navarro MA, Casamitjana R, Soler J (2004) Relationship between 25-(OH) D3, the IGF-1 system, leptin. Anthropometric and body composition variables in the healthy randomly selected population. Horm Metab Res 36:48–53
Parikh G, Varadinova M, Suwandhi P et al (2010) Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res 42:754–757

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