Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR−/− and LDLR+/+ mice
Immunity, Inflammation, and Disease: 10.1002/iid3.154
Ramiar Kheder, James Hobkirk, Zeayd Saeed, Justyna Janus, Sean Carroll, Michael J. Browning, Cordula Stover cms13 at le.ac.uk
- Mice designed to get diabetes often failed to get diabetes if they had lots of vitamin D during their lives – Feb 2014
- Prediabetes progression to diabetes 25 percent less for every 4 ng increase in vitamin D – April 2012
- Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
- Death by Sugar
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
448 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
22 ; Intervention 48 ; Meta-analysis 28 ; Obesity 26 ; Pregnancy 39 ; T1 (child) 34 ; Omega-3 10 ; Vitamin D Receptor 18 ; Genetics 10 ; Magnesium 18 Click here to see details
Diabetes category starts with the following
448 items In Diabetes category Autoimmune category listing has 162 items along with related searches
Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D3, to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity.
We analyzed female LDLR−/− and LDLR+/+ mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation.
The groups on a high fat high sugar diet with supplementary Vitamin D3, in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there was less pericentral hepatic steatosis. Levels of non-esterified fatty acids and lipid peroxidation products were significantly lower in the group supplemented with additional Vitamin D3, as were systemic markers of inflammation (serum endotoxin and IL-6). M2 macrophage phenotype predominated in the group supplemented with additional Vitamin D3. Beneficial changes were observed as early as five weeks’ supplementation with Vitamin D3 and extended to restoration of high fat high sugar diet induced decrease of bone mineral density.
In summary, Vitamin D3 was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR−/− and LDLR+/+ mice.
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