First Received on May 4, 2011.
Sponsor: University of Toronto
ClinicalTrials.gov Identifier: NCT01348594
Infertility is a common and psychologically devastating problem for 20% of Canadian couples. Approximately, 20% of infertile couples are diagnosed with unexplained infertility and left without an explanation for their inability to have a baby. Pathological uterine receptivity and embryo implantation are hypothesized mechanisms underlying sub-fertility in these couples. Embryo implantation requires a complicated sequence of events involving the differentiation of endometrial cells to attain uterine receptivity and the synchronized interaction between maternal and embryonic tissues. Vitamin D has been hypothesized to play a role in this poorly understood process. Vitamin D is a known regulator of signal transduction pathways involved in embryo implantation and its receptors are involved in calcium-regulation in various reproductive tissues including, the ovary, uterus, and placenta.
In Canada, the prevalence of Vitamin D insufficiency is approximately 34-50%. The goal of the proposed study is to determine the prevalence of vitamin D insufficiency in an infertile population and whether this prevalence is higher than in average Canadian reproductive age women. More importantly, we will investigate whether vitamin D insufficiency in our infertile population translates to impaired implantation and reduced clinical pregnancy rates. Insight into vitamin D's role in reproduction is essential not only to provide scientific understanding of the mechanism underlying embryo implantation, but also because vitamin D supplementation could provide an easy and safe means of treating infertility.
52.5% with adequate vitamin D vs 35% for whose levels were insufficient or deficient.
No indication if there was any vitamin D intervention
- Also test the vitamin D level of the donor
- Add a random controlled trial of adding 4,000 IU of vitamin D and some co-factors
- Fertility and Sperm
71 items in VitaminDWiki category
- In Vitro Fertilization (D5 SET ICSI) 40 percent more successful if high vitamin D – Sept 2014
- Overview Women and Vitamin D
- Overview Moms babies and vitamin D
Vitamin D increases fertility of both the man and the women.
Each 1 ng increase in blood level of vitamin D increases fertility by 1%.
You may not have heard much about it since it was was patented back in 1990.
It has been used by zoos and vets for a long time.
- 63% having conception problems were Vitamin D deficient and 100% of those which specific problems had normal vitamin D level
- More details on the above information from Natural-Fertility-Info.com
- Vitamin D: The Wonder Vitamin That May Help Me ConceiveIVF
- The men also need vitamin D- Dr. Sorenson, author of Vitamin D3 and Solar Power
- Vitamin D Boosts IVF Success
- Patent granted 1990 for improving fertility by giving vitamin D to females or males - of any mammal
- We can now see why there are few claims that vitamin D will improve fertility - the claimer might have to pay fees to the patent holder
- 60 second video on improving fertility of the women and the man with vitamin D
- At VitaminDWiki: Better sperm if have higher level of vitamin D
- Peak months for births in Czech Republic were March to May - 9 months after peak vitamin D blood levels
- NYT article from 1990 - one of the peak conception times is Oct & Nov
- Better sperm if have higher level of vitamin D - has lots of details and links
- Vitamin D and pregnancy revisited each 1 ng increases chance of pregnancy by 1 percent - 2010
- Vitamin D and fertility and birth problems with dark skin – Jan 2011
- Fertitility improved with Vitamin D – systematic review Jan 2012