Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis.
Cancer Causes Control. 2011 Jan 4.
Gilbert R, Martin RM, Beynon R, Harris R, Savovic J, Zuccolo L, Bekkering GE, Fraser WD, Sterne JA, Metcalfe C.
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK, Becky.Gilbert at Bristol.ac.uk.
OBJECTIVE: We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)(2)D) concentrations) with prostate cancer.
METHODS: We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response random-effects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I(2) statistic quantified between-study variation due to heterogeneity.
RESULTS: Twenty-five papers were included. In prospective studies, the
OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I (2) = 0%) for total prostate cancer and
0.93 (3 studies; 0.63, 1.39; I (2) = 25%) for aggressive prostate cancer.
Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I (2) = 49%).
The OR per 10 ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I (2) = 0%) for total prostate cancer and
0.98 (6 studies; 0.84, 1.15; I (2) = 32%) for aggressive prostate cancer.
The OR per 10 pg/mL increase in 1,25(OH)(2)D was 1.00 (7 studies; 0.87, 1.14; I (2) = 41%) for total prostate cancer and
0.86 (2 studies; 0.72, 1.02; I (2) = 0%) for aggressive prostate cancer.
CONCLUSION: Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression. PMID: 21203822
The vitamin D saga … another data analysis at ProstateCancerInfoLink
- In a total of six studies, the OR for a finding of aggressive prostate cancer was 0.84 for each 10 ng/ml increase in dietary intake of 25-hydroxy vitamin D.
- (this does not appear to be in the abstract)