Translate Register Log In Login with facebookLogin and Register

UV light does not activate immunity genes, but Vitamin D supplements do – Feb 2017

Randomized clinical trial in vitamin D-deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood.

Am J Clin Nutr. 2017 Feb 22. pii: ajcn150367. doi: 10.3945/ajcn.116.150367. [Epub ahead of print]
Ponda MP1, Liang Y2, Kim J3, Hutt R2, Dowd K2, Gilleaudeau P3, Sullivan-Whalen MM3, Rodrick T4, Kim DJ3, Barash I5, Lowes MA3, Breslow JL4.
1Laboratory of Biochemical Genetics and Metabolism, mponda at rockefeller.edu.
2Rockefeller University Hospital Center for Clinical and Translational Science, and.
3Laboratory of Investigative Dermatology, The Rockefeller University, New York, NY; and.
4Laboratory of Biochemical Genetics and Metabolism.
5Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Background: Vitamin D deficiency, defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration <20 ng/mL, is correlated with a more atherogenic lipid profile. However, oral vitamin D supplementation does not lower LDL-cholesterol concentrations or raise HDL-cholesterol concentrations. This uncoupling between association and causation may result from a failure of oral vitamin D to mimic the effect of dermally synthesized vitamin D in response to ultraviolet type B (UVB) light.

Objective: We tested the hypothesis that, in vitamin D-deficient adults, the replenishment of vitamin D with UVB exposure would lower LDL-cholesterol concentrations compared with the effect of oral vitamin D3 supplementation.

Design: We performed a randomized clinical trial in vitamin D-deficient adults and compared vitamin D replenishment between subjects who received oral vitamin D3 (n = 60) and those who received narrow-band UVB exposure (n = 58) ≤6 mo.

Results: There was no difference in the change from baseline LDL-cholesterol concentrations between oral vitamin D3 and UVB groups (difference in median of oral vitamin D3 minus that of UVB: 1.5 mg/dL; 95% CI: -5.0, 7.0 mg/dL). There were also no differences within groups or between groups for changes in total or HDL cholesterol or triglycerides. Transcriptional profiling of skin and blood, however, revealed significant upregulation of immune pathway signaling with oral vitamin D3 but significant downregulation with UVB.

Conclusions: Correcting vitamin D deficiency with either oral vitamin D3 or UVB does not improve the lipid profile. Beyond cholesterol, these 2 modalities of raising 25(OH)D have disparate effects on gene transcription.

This trial was registered at clinicaltrials.gov as NCT01688102.

PMID: 28228421 DOI: 10.3945/ajcn.116.150367

Publisher rents the PDF for $8

See also VitaminDWiki

184 items in Immunity category

    see also

Virus category listing has 127 items along with related searches

Overview Influenza and vitamin D
Search for treg OR "t-cell" in VitaminDWiki 610 items as of March 2017
Search VitaminDWiki for INFECTION 1870 items as of April 2016
Search VitaminDWik for INFECTION in title 79 items as of March 2017

Vitamin D Every Day to Keep the Infection Away 2015 file
shows increasing publications on vitamin D and Infection

All of the studies in Breathing and Immunity are listed here:

Immunity Intervention trials using Vitamin D:

Most visited 10 pages in Immunity category

Id Page Hits Last modification Creator Categories
1304 Overview Influenza and vitamin D 144957
24 Sep, 2018 17:20
admin Immunity
5833 Vitamin D may protect against Ebola 57064
01 May, 2016 23:36
admin Immunity
1410 Vaginal suppository of 6300 IU vitamin D stopped vaginal infection – Feb 2011 39378
11 Mar, 2019 12:13
Editor Immunity
Forms of Vitamin D
3434 Immunity 34142
18 Feb, 2018 18:38
ricks99 Immunity
1310 Yeast Infection and Vitamin D 33676
11 Mar, 2019 12:12
admin Immunity
7335 virus Zika - ¿Cómo reducir significativamente su riesgo? 28562
22 Apr, 2016 14:31
admin Immunity
5818 Antimicrobial peptides (which attack pathogens) are increased by Vitamin D 23395
01 Sep, 2016 13:46
admin Autoimmune
7281 Zinc and Vitamin D 23365
25 Dec, 2018 18:55
admin Immunity
6434 Respiratory infections cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015 18726
22 Dec, 2018 21:10
admin Breathing
Intervention - non daily
4518 Major interactions between Vitamin D, Vitamin A, and Influenza – Sept 2013 17328
05 Dec, 2014 16:49
admin Immunity
Vitamin D and Vitamin A

See any problem with this page? Report it (FINALLY WORKS)