Am J Clin Nutr May 10, 2017, doi: 10.3945/ajcn.116.145607
Alexandra C Purdue-Smithe3, Brian W Whitcomb3, Kathleen L Szegda3, Maegan E Boutot3, JoAnn E Manson5–7, Susan E Hankinson3,5,7, Bernard A Rosner8, Lisa M Troy4, Karin B Michels5–7, and Elizabeth R Bertone-Johnson3, ebertone at schoolph.umass.edu
3 Departments of Biostatistics and Epidemiology, and
4 Nutrition, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA;
5 Channing Division of Network Medicine and
6 Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and
7 Departments of Epidemiology and
8 Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA
- ALL of the top 10 health problems of women are associated with low vitamin D
- The Role of Vitamin D in Menopausal Medicine – Jan 2016
- Poor menstrual cycles 2X more likely if poor vitamin D levels - many studies
- Vitamin D and menopause -A narrative review – July 2014
- Menopause 3 years later in women eating fatty fish (Omega-3) – April 2018
- Premature menopause increases risk having multiple health problems by 3X (low vitamin D not mentioned) – Jan 2020
Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects ∼10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk factors for early menopause have been identified, but emerging data suggest that high vitamin D intake may reduce risk.
Objective: We evaluated how intakes of vitamin D and calcium are associated with the incidence of early menopause in the prospective Nurses’ Health Study II (NHS2).
Design: Intakes of vitamin D and calcium from foods and supplements were measured every 4 y with the use of a food-frequency questionnaire. Cases of incident early menopause were identified from all participants who were premenopausal at baseline in 1991; over 1.13 million person-years, 2041 women reported having natural menopause before the age of 45 y. We used Cox proportional hazards regression to evaluate relations between intakes of vitamin D and calcium and incident early menopause while accounting for potential confounding factors.
Results: After adjustment for age, smoking, and other factors, women with the highest intake of dietary vitamin D (quintile median: 528 IU/d) had a significant 17% lower risk of early menopause than women with the lowest intake [quintile median: 148 IU/d; HR: 0.83 (95% CI: 0.72, 0.95); P-trend = 0.03].
Dietary calcium intake in the highest quintile (median: 1246 mg/d) compared with the lowest (median: 556 mg/d) was associated with a borderline significantly lower risk of early menopause (HR: 0.87; 95% CI: 0.76, 1.00; P-trend = 0.03). Associations were stronger for vitamin D and calcium from dairy sources than from nondairy dietary sources, whereas high supplement use was not associated with lower risk.
Conclusions: Findings suggest that high intakes of dietary vitamin D and calcium may be modestly associated with a lower risk of early menopause. Further studies evaluating 25-hydroxyvitamin D concentrations, other dairy constituents, and early menopause are warranted.