Toggle Health Problems and D

Pancreatic Cancer risk increases with additional 100 IU of dietary vitamin D (really strange) – May 2015

Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.

Ann Oncol. 2015 May 14. pii: mdv236. [Epub ahead of print]
Waterhouse M1, Risch HA2, Bosetti C3, Anderson KE4, Petersen GM5, Bamlet WR5, Cotterchio M6, Cleary SP7, Ibiebele T8, La Vecchia C9, Skinner H10, Strayer L4, Bracci PM11, Maisonneuve P12, Bueno-de-Mesquita HB13, Zatoński W14, Lu L2, Yu H15, Janik-Koncewicz K14, Neale RE1; Pancreatic Cancer Case-Control Consortium (PanC4).
Author information
1Population Health Division, QIMR Berghofer Medical Research Institute, Herston, Australia Centre for Research Excellence in Sun and Health, Queensland University of Technology, Kelvin Grove, Australia.
2Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, USA.
3Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy.
4Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA.
5Department of Health Sciences Research, Mayo Clinic, Rochester, USA.
6Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
7Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada Department of Surgery, University of Toronto, Toronto, Canada.
8Population Health Division, QIMR Berghofer Medical Research Institute, Herston, Australia.
9Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
10Truven Health Analytics, Durham, USA.
11Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, USA.
12Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
13National Institute for Public Health and the Environment, Bilthoven, The Netherlands Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.
14Department of Epidemiology, The Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
15Epidemiology Program, University of Hawaii Cancer Center, Honolulu, USA.

The potential role of vitamin D in the aetiology of pancreatic cancer is unclear, with recent studies suggesting both positive and negative associations.

We used data from 9 case-control studies from the International Pancreatic Cancer Case-Control Consortium (PanC4) to examine associations between pancreatic cancer risk and dietary vitamin D intake. Study-specific odds ratios (ORs) were estimated using multivariable logistic regression, and ORs were then pooled using a random effects model. From a subset of 4 studies, we also calculated pooled estimates of association for supplementary and total vitamin D intake.

Risk of pancreatic cancer increased with dietary intake of vitamin D (per 100 international units (IU)/day: OR=1.13, 95% confidence interval (CI) 1.07-1.19, p=7.4×10-6, p-heterogeneity=0.52; ≥230 vs <110 IU/day: OR=1.31, 95% CI 1.10-1.55, p=2.4×10-3, p-heterogeneity=0.81), with the association possibly stronger in people with low retinol / vitamin A intake.

Increased risk of pancreatic cancer was observed with higher levels of dietary vitamin D intake. Additional studies are required to determine whether or not our finding has a causal basis.

PMID: 25977560

Publisher wants $39 for the PDF

See also VtiaminDWIki