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No association found between melanoma and low vitamin D levels – Sept 2012

Pre-diagnostic circulating vitamin D and risk of melanoma in men.
PLoS One. 2012;7(4):e35112. Epub 2012 Apr 25.
Major JM, Kiruthu C, Weinstein SJ, Horst RL, Snyder K, Virtamo J, Albanes D.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America. jacqueline.major at nih.gov

PURPOSE:
Various studies have examined the association between serum vitamin D levels and different cancers; however, this is the first prospective study of this association with melanoma risk. The aim of this study is to investigate the association between serum vitamin D [25(OH)D] levels and melanoma in a cohort of older, middle-aged Finnish male smokers.

METHODS:
We conducted a nested case-control study within the Alpha-Tocopherol Beta-Carotene Cancer Prevention (ATBC) Study. From the ATBC cohort, 368 subjects were chosen for our study; 92 participants that developed melanoma and 276 matched control subjects. At study baseline, lifestyle questionnaires and blood samples were collected. Serum 25(OH)D was modeled as three sets of categorical variables: clinically-defined categories, season-specific quartiles and season-adjusted residual quartiles. Conditional logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (95% CIs) to estimate the association between circulating vitamin D and melanoma risk.

RESULTS:
Overall no association of serum 25(OH)D and melanoma risk was observed.
A decreased risk of developing melanoma was observed in the middle categories compared to the lowest category, albeit not significant.

CONCLUSION:
Results indicate no association between serum 25(OH)D levels and melanoma.
Additional studies, including possibly consortium efforts, are needed to investigate the association between serum 25(OH)D levels and risk of melanoma in larger, more diverse study populations.
Image

PMID: 22558121

PDF is attached at the bottom of this page
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Note: Their top category is >20 ng - vitamin D typically helps for levels > 40ng

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
1595 Melanoma T2.jpg admin 12 Sep, 2012 02:48 69.14 Kb 890
1594 Melanoma vitamin D.pdf PDF admin 12 Sep, 2012 02:39 78.99 Kb 796
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