Vitamin A and D deficiencies affect antibody isotype distribution and the respiratory virus-specific immune response (VIR5P.1161)
The Journal of Immunology, May 1, 2015, vol.194 (1 Supplement) 148.29 (meeting)
Julia Hurwitz1, Bart Jones1, Robert Sealy1, Rhiannon Penkert1, Paul Thomas1 and Sherri Surman1
1St. Jude Children's Research Hospital, Memphis, TN
Vitamins A and D are highly interactive in their binding of receptor complexes RAR-RXR and VDR-RXR, which regulate genes essential for normal immune function. To determine how vitamins impact the immune response toward respiratory viruses, we employed mice deficient in vitamin A (VAD), vitamin D (VDD), or both. Analysis of virus-specific antibody-forming cells (AFCs) in VAD mice following influenza virus infection revealed a reduction in IgA-producing AFCs in the respiratory tract mucosa, a first line of defense against respiratory viruses. The IgG/IgA ratio was increased in VAD, but not VDD mice.
Interestingly, in double-deficient mice, inhibition was exacerbated to the extent that there were virtually no detectable virus-specific AFCs in the lower respiratory tract.
To determine if vitamin deficiencies impact antibody isotypes in humans, we examined blood samples from residents of Memphis, TN. A substantial fraction of individuals exhibited low levels of vitamin A, D or both. As in mice, vitamin A and IgA levels were correlated. When vitamin A was low, antibody isotypes encoded by CH genes at the 3’ end of the heavy chain locus (IgA and IgG2) were poorly represented relative to those encoded at the 5’ end (IgM, IgG3 and IgG1), indicating abnormal CH switching or improper maturation or stability of switched AFCs. Results help explain how vitamin deficiencies render humans vulnerable to respiratory virus disease and encourage rapid implementation of corrective measures.
See also VitaminDWiki
- Immunity category listing has
249 items along with related searches
- Fewer white blood cells needed to deal with infection when higher levels of vitamin D – Aug 2017
- The TOP articles in Vitamin D and Vitamin A are:
Immune response was poor in mice and humans with low vitamin D and low vitamin A – May 2015
- Synergism between Vitamin D, Vitamin K-2, and Vitamin A: Masterjohn – Sept 2013
- Interactions of Vitamins D, A, and K, should measure calcitriol, calcification – Masterjohn Aug 2013
- 45 ng vitamin D may be enough (what about vitamin A)- Aug 2013
- Response to high dose vitamin D is limited by vitamin A - July 2013
- 8X higher Osteoporosis risk if high level of vitamin A, vitamin D important too – Feb 2013
- 2X more complications after heart surgery associated with high level of vitamin D – Jan 2013
- Low cost cofactors for vitamin D
3378 visitors, last modified 17 Aug, 2017,This page is in the following categories (# of items in each category)