Vitamin D and the Skin: An Update for Dermatologists
American Journal of Clinical Dermatology, pp 1–13
Elio Kechichian, Khaled Ezzedine
Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this category of patients at risk for vitamin D deficiency.
Maintaining a vitamin D serum concentration within normal levels is warranted in
- atopic dermatitis,
- psoriasis,
- vitiligo,
- polymorphous light eruption,
- mycosis fungoides,
- alopecia areata,
- systemic lupus erythematosus, and
- melanoma patients.
The potential determinants of vitamin D status, as well as the benefits and risks of vitamin D (with a special focus on the skin), will be discussed in this article.
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