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Vitamin D and the Pathophysiology of Inflammatory Skin Diseases.

Skin Pharmacol Physiol. 2018 Jan 6;31(2):74-86. doi: 10.1159/000485132. [Epub ahead of print]
Umar M1, Sastry KS, Al Ali F, Al-Khulaifi M, Wang E, Chouchane AI.
Research Department, Division of Translational Medicine, Sidra Medicine, Doha, Qatar.


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Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis.

A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like "vitamin D," "skin," "atopic dermatitis," and "psoriasis." Only articles published in English and related to the study topic were included in this review.

Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders.

Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

Created by admin. Last Modification: Monday January 8, 2018 18:18:32 GMT-0000 by admin. (Version 6)

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9149 Skin Converts Vitamin D red lines.jpg admin 08 Jan, 2018 18:17 48.05 Kb 679
9148 Skin Converts Vitamin D zoom.jpg admin 08 Jan, 2018 17:50 46.70 Kb 262
9147 Inflamatory skin.pdf PDF 2018 admin 08 Jan, 2018 17:49 234.54 Kb 708
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