Toggle Health Problems and D

Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018

Oral vitamin D3 supplementation for chronic plaque psoriasis: A randomized, double-blind, placebo-controlled trial.

J Dermatolog Treat. 2018 Feb 26:1-34. doi: 10.1080/09546634.2018.1444728
Ingram MA1, Jones MB2, Stonehouse W3, Jarrett P4,5, Scragg R6, Mugridge O1, von Hurst PR1.
1 School of Sport, Exercise and Nutrition, Massey Univ., Albany Campus , Private Bag 102904 , North Shore City , Auckland 0745 , New Zealand.
2 Institute of Natural and Mathematical Sciences, Massey Univ., Albany Campus , Private Bag 102904 , North Shore City , Auckland 0745 , New Zealand.
3 Commonwealth Scientific and Industrial Research Organisation, Food and Nutrition Flagship , Adelaide , South Australia 5000 , Australia.
4 Department of Dermatology , Middlemore Hospital , Otahuhu , Auckland 1640 , New Zealand.
5 Department of Medicine , The University of Auckland , Auckland 1072 , New Zealand.
6 School of Population Health, The University of Auckland , Auckland 1142 , New Zealand.


Partials of Psoriasis Area and Severity Index

Purpose The management of psoriasis remains a challenge for dermatologist and patient. This study aimed to determine whether vitamin D3 supplementation improves psoriasis compared to placebo.

Materials and methods In a randomized, doubled-blind, placebo-controlled trial, 101 participants ≥18 years with psoriasis were grouped by severity and allocated to 100,000 International Units (IU) vitamin D3/month for 12 months (200,000 IU at baseline; n = 67) or an identical placebo (n = 34). Psoriasis Area and Severity Index (PASI) and serum 25(OH)D concentrations were assessed at 3-monthly intervals. The primary outcome was the difference in PASI between groups over time. The relationship between 25(OH)D and PASI across the sample was also considered in a post hoc analysis.

Results PASI did not differ between groups at any time (group F(1,104)=0.48, P = 0.49; group*time F(4,384)=0.26, P = 0.90). However, 25(OH)D increased in both groups, rendering these findings inconclusive. A significant inverse relationship existed between PASI and 25(OH)D, with elevation of 25(OH)D by up to 125 nmol/L associated with mild decreases in PASI (estimated range of decrease 0 - 2.6; P = 0.002).
 Download the PDF from Sci-Hub via VitaminDWiki

Cited by 34 studies in Google Scholar as of March 2023

Google Scholar

  • Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy Aug 2022
    • https://doi.org/10.3390/ijms23158575 FREE PDF
  • Effectiveness of oral vitamin D supplementation in lessening disease severity among patients with psoriasis: A systematic review and meta-analysis of randomized controlled trials - Feb 2021 https://doi.org/10.1016/j.nut.2020.111024 PDF is behind a paywall
    • Examined of 7 out of 5,000 studies. Did not find an association

Psoriasis in VitaminDWiki

Some of the 70 Psoriasis articles
There have been 4072 visitors to this page

Created by admin. Last Modification: Thursday March 30, 2023 16:57:34 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
19403 Psoraisis residuals.jpg admin 30 Mar, 2023 48.00 Kb 204
19402 response 100K per month.jpg admin 30 Mar, 2023 25.33 Kb 278
19401 Psoraisis 2018_CompressPdf.pdf admin 30 Mar, 2023 306.24 Kb 84