Diurnal fluctuations in biochemical parameters related to calcium homeostasis – the Bispebjerg study of diurnal variations
Scandinavian J. of Clinical and Lab. Investigation https://doi.org/10.1080/00365513.2024.2392116
Silje J. Borge, Henriette P. Sennels ORCID Icon, Peter Schwar ORCID Icon & Henrik L. Jørgensen ORCID Icon
Purpose
This aim of this study was to assess the possible association between diurnal oscillations and biochemical markers associated with calcium homeostasis. This included the markers parathyroid hormone (PTH), total calcium, total alkaline phosphatase, phosphate, and 25-hydroxyvitamin D (25-OH-D). By examining the influence of circadian rhythms on these parameters, the study aimed to deepen the understanding of calcium metabolism dynamics and its clinical implications.
Patients and methods
Blood samples from 24 Caucasian male volunteers aged 20 to 40 (mean age 26) with normal pulse, blood pressure, and BMI were analyzed for biochemical markers related to calcium homeostasis. Data was obtained from the Bispebjerg study of diurnal variations. Blood samples were collected every three hours over a 24-hour period. Patients were fasting from 22:00 to 09:00. The participants spent 24 h in the hospital ward, receiving regular meals and engaging in low-intensity activities. They experienced 15 h of daylight and 9 h of complete darkness during sleep. Diurnal oscillations were analyzed using cosinor analysis with statistical significance set at p < 0.05.
Results
Total calcium, phosphate, and PTH exhibited significant diurnal variations. Total calcium and PTH were inversely synchronized while PTH and phosphate oscillated in synchronization. The three parameters showed relatively large amplitude/reference range ratios from 25.4% to 41.5%.
Conclusion
This study found notable fluctuations in total calcium, phosphate, and PTH levels over a 24-hour cycle, while 25-OH-D and total alkaline phosphatase remained consistent. It highlights the importance of considering sampling times for total calcium, PTH, and phosphate in clinical settings.
VitaminDwiki – Calcium category contains
Calcium often causes major health problems
- Many studies have identified many health problems with Calcium supplementation
- Less than 750 mg of Calcium supplement daily - VitaminDWiki has recommended for 7 years
- Some believe that the health problems are due to the spike in blood Calcium from taking the Calcium only once per day - Dr. Greger - March 2018 text and short video
- Perhaps there would be a shorter Calcium spike (and less of a problem) if take Calcium multiple times a day
- Perhaps also less of a problem if the Calcium is plant-based
- Calcium from milk also causes 5+ major health problems 2015 Dr. Greger
- No apparent health problems from processed dairy products (cheese, yogurt, etc)
- Calcium supplements are less of a problem if have adequate Vitamin K
- which keeps Calcium from forming blood-system plaque
- 2.7X increase in rate of Colon polyps in 6-10 years RCT March 2018
- Calcium from food or supplements associated with more deaths (US Cohort of 31,000 people) – April 2019
VitaminDwiki – PTH and Vitamin D - many studies
4 of 183,000 related articles in Google Scholar
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