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Breast cancer 36 percent less likely for each 4 ng increase in vitamin D – Sept 2018

Serum 25-hydroxyvitamin D and breast cancer risk by pathological subtype (MCC-Spain).

J Steroid Biochem Mol Biol. 2018 Sep;182:4-13. doi: 10.1016/j.jsbmb.2018.04.005. Epub 2018 Apr 19.
Lope V1, Castelló A1, Mena-Bravo A2, Amiano P3, Aragonés N4, Fernández-Villa T5, Guevara M6, Dierssen-Sotos T7, Fernandez-Tardón G8, Castaño-Vinyals G9, Marcos-Gragera R10, Moreno V11, Salas-Trejo D12, Diaz-Santos M13, Oribe M14, Romieu I15, Kogevinas M9, Priego-Capote F2, Pérez-Gómez B1, Pollán M16.

PDF is available free at Sci-Hub   10.1016/j.jsbmb.2018.04.005

Epidemiologic evidence on the association between vitamin D and breast cancer is still inconclusive. This study analyzes the association between serum 25-hydroxyvitamin D (25(OH)D) and breast cancer risk by pathologic subtype, stage at diagnosis and specific breast cancer risk factors. We conducted a population-based multicase-control study where 546 histologically-confirmed breast cancer cases and 558 population controls, frequently matched by geographic area, age and body mass index, were recruited in 12 Spanish provinces (MCC-Spain).
Information was collected by a questionnaire and plasma 25(OH)D was measured by solid-phase extraction on-line coupled to liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS). Odds ratios and 95% confidence intervals were calculated using logistic and multinomial mixed regression models. We found a clear protective effect between 25(OH)D levels and breast cancer risk, with a significant dose-response trend (OR per 10 nmol/L = 0.88; 95%CI = 0.82-0.94). While no differences were observed between pre and postmenopausal women, stage at diagnosis, or across strata of the main breast cancer risk factors, the protection was more pronounced for triple negative tumors (OR per 10 nmol/L = 0.64; p-heterogeneity = 0.038). Similar results were observed when only cases sampled in the first month after diagnosis were considered. The protective effect of vitamin D on breast cancer risk may be subtype specific, being stronger for more aggressive tumors, which provides a new approach to prevent this disease.

Created by admin. Last Modification: Monday October 15, 2018 18:14:32 GMT-0000 by admin. (Version 3)