Vitamin D Metabolism and Profiling in Veterinary Species
Review Metabolites. 2020 Sep 15;10(9):E371. doi: 10.3390/metabo10090371.
Overview Veterinary and vitamin D has the following
Veterinary category hasAnimals need Vitamin D too
- Vitamin D is important for pregnancies (pigs as well as people)– Sept 2022
- Many Vitamin D similarities: people and cows - March 2022
- Several advanced-maternal-age problems reduced if given Vitamin D during pregnancy (mice in this case) – July 2021
- Poor immune system associated with low Vitamin D (dogs in this case) – June 2020
- Chicken bones, eggs, and activated vitamin D in eggs increased with 2 hours of daily UVB – Dec 2019
- Vitamin D in eggs increased 4X after UV lighting near legs was added – April 2019
- Hens with Vitamin D were better in at least 5 ways – RCT Aug 2018
Pets as well
- Critically ill dogs with good levels of vitamin D have much better outcomes (humans too) – March 2018
- Half of dogs now get cancer, it used to be just 1 percent (probably low Vitamin D)
- Dogs, cats, rabbits, guinea pigs, pet birds, etc need Vitamin D
- Dogs with Cancer have low vitamin D, same as humans – Sept 2017
- Companion animals (dog, cats) need vitamin D too – March 2016
- Hospitalized cats 8X more likely to die if low vitamin D (Vit. D helps humans too) – May 2015
- Rickets increasing in dogs
Farm Vets are paid when their "patients" are healthy,
vs doctors who are paid only when "patients" become sick
_Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)
Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')
Virtually all US farmers who raise livestock use feed which is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight
Download the PDF from VitaminDWiki
The demand for vitamin D analysis in veterinary species is increasing with the growing knowledge of the extra-skeletal role vitamin D plays in health and disease. The circulating 25-hydroxyvitamin-D (25(OH)D) metabolite is used to assess vitamin D status, and the benefits of analysing other metabolites in the complex vitamin D pathway are being discovered in humans. Profiling of the vitamin D pathway by liquid chromatography tandem mass spectrometry (LC-MS/MS) facilitates simultaneous analysis of multiple metabolites in a single sample and over wide dynamic ranges, and this method is now considered the gold-standard for quantifying vitamin D metabolites. However, very few studies report using LC-MS/MS for the analysis of vitamin D metabolites in veterinary species. Given the complexity of the vitamin D pathway and the similarities in the roles of vitamin D in health and disease between humans and companion animals, there is a clear need to establish a comprehensive, reliable method for veterinary analysis that is comparable to that used in human clinical practice. In this review, we highlight the differences in vitamin D metabolism between veterinary species and the benefits of measuring vitamin D metabolites beyond 25(OH)D. Finally, we discuss the analytical challenges in profiling vitamin D in veterinary species with a focus on LC-MS/MS methods.
| 2278 visitors, last modified 19 Sep, 2020, |
| ID | Name | Comment | Uploaded | Size | Downloads | |
|---|---|---|---|---|---|---|
| 14330 | 1,25.jpg | admin 19 Sep, 2020 11:48 | 52.56 Kb | 329 | ||
| 14329 | 3-epi.jpg | admin 19 Sep, 2020 11:48 | 41.56 Kb | 353 | ||
| 14328 | 25(OH).jpg | admin 19 Sep, 2020 11:47 | 84.10 Kb | 372 | ||
| 14327 | Vitamin D Metabolism in animals.pdf | PDF 2020 | admin 19 Sep, 2020 11:47 | 2.84 Mb | 318 |