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Vitamin D types and amounts vary widely between humans and animals – Sept 2020

Vitamin D Metabolism and Profiling in Veterinary Species

Review Metabolites. 2020 Sep 15;10(9):E371. doi: 10.3390/metabo10090371.

VitaminDWiki

Overview Veterinary and vitamin D has the following

Veterinary category has 130 items

Vets give 3X vitamin D than the US govt recommends for animal OR humans

Farm Vets are paid when their "patients" are healthy,
   vs doctors who are paid only when "patients" become sick

A few Vet items in VitaminDWiki

Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)

Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')

Virtually all US farmers who raise livestock use feed which is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight
Parrot-like birds are given 600 IU per pound of feed

The cow experts probably base their ideas on

- what is needed,
- what actually works,
- what is cost effective (vitamin D for a cow costs about $1/year), and
- what does not have ANY long-term bad side-affects

Vet-grade Vitamin D: $50 million for the entire US population for a year.

Cow owners use really low cost vitamin D
Vitamin D costs the owner $1/cow for an entire year for a dose rate which is effectively 10,000 IU for a normal weight human.
Assuming that you want to give say 7,000 IU of vitamin D to every person in the US
And since a person weighs about 1/5 that of a cow, 7,000 IU vitamin D would be about 16 cents per year (vet grade)
Thus the cost of vet-grade vitamin D for the entire US population would be approximately
311 million * 16 cents = $50 million

 Download the PDF from VitaminDWiki
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The demand for vitamin D analysis in veterinary species is increasing with the growing knowledge of the extra-skeletal role vitamin D plays in health and disease. The circulating 25-hydroxyvitamin-D (25(OH)D) metabolite is used to assess vitamin D status, and the benefits of analysing other metabolites in the complex vitamin D pathway are being discovered in humans. Profiling of the vitamin D pathway by liquid chromatography tandem mass spectrometry (LC-MS/MS) facilitates simultaneous analysis of multiple metabolites in a single sample and over wide dynamic ranges, and this method is now considered the gold-standard for quantifying vitamin D metabolites. However, very few studies report using LC-MS/MS for the analysis of vitamin D metabolites in veterinary species. Given the complexity of the vitamin D pathway and the similarities in the roles of vitamin D in health and disease between humans and companion animals, there is a clear need to establish a comprehensive, reliable method for veterinary analysis that is comparable to that used in human clinical practice. In this review, we highlight the differences in vitamin D metabolism between veterinary species and the benefits of measuring vitamin D metabolites beyond 25(OH)D. Finally, we discuss the analytical challenges in profiling vitamin D in veterinary species with a focus on LC-MS/MS methods.


Created by admin. Last Modification: Saturday September 19, 2020 11:51:42 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
14330 1,25.jpg admin 19 Sep, 2020 11:48 52.56 Kb 34
14329 3-epi.jpg admin 19 Sep, 2020 11:48 41.56 Kb 33
14328 25(OH).jpg admin 19 Sep, 2020 11:47 84.10 Kb 35
14327 Vitamin D Metabolism in animals.pdf PDF 2020 admin 19 Sep, 2020 11:47 2.84 Mb 32
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