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Vitamin D should improve the clotting function (COVID-19 storms, etc.) – Feb 2021

Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives

Mol Cell Biochem. 2021 Feb 18. doi: 10.1007/s11010-021-04093-6
Tanusree Sengupta 1, Rinku Majumder 2, Samarpan Majumder 3

VitaminDWiki

Blood clotting (Thrombosis) is associated with low Vitamin D (yet again)
Also, Vitamin D appears to reduce or eliminate the cytokine storms

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Aggressive inflammatory response leading to hypercoagulability has been found to be associated with disease severity in COVID-19 patients and portends bad treatment outcome. A state of acute disseminated intravascular coagulation (DIC), along with pulmonary embolism and/or deep vein thrombosis, has been observed in critically ill ICU patients. Autopsy reports of COVID-19 patients demonstrated microthrombi in lungs and in other organs, as well as marked inflammatory changes, characteristic clinicopathological features that exacerbate disease severity. Vitamin D supplementation was recommended by many clinicians across the globe to improve clinical symptoms of COVID-19 patients, mainly because of its immunomodulatory roles on immune cells. Furthermore, vitamin D and its associated molecules are also known to directly or indirectly regulate various thrombotic pathways.
We propose that vitamin D supplementation not only attenuates the risk of Acute Respiratory Disease Syndrome (ARDS) but it also may have a role in reducing coagulation abnormalities in critically ill COVID-19 patients. The overarching goal of this review is to discuss the effects of vitamin D on coagulation pathways and other intertwined processes leading to thrombosis. Many clinical trials are currently investigating the efficacy of vitamin D supplementation in reducing the risk of COVID-19 infection. However, randomized placebo control clinical trials are also necessary to ascertain the effect of vitamin D supplementation on reducing the risk of coagulopathy in COVID-19 patients.


Created by admin. Last Modification: Saturday February 20, 2021 17:31:52 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
15077 Thromsosis studies.jpg admin 20 Feb, 2021 17:15 82.57 Kb 101
15076 clot.pdf PDF 2021 admin 20 Feb, 2021 17:14 573.61 Kb 33
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