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Vitamin D should improve the clotting function (COVID-19 storms, etc.) – Feb 2021

Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives

Mol Cell Biochem. 2021 Feb 18. doi: 10.1007/s11010-021-04093-6
Tanusree Sengupta 1, Rinku Majumder 2, Samarpan Majumder 3

VitaminDWiki

Blood clotting (Thrombosis) is associated with low Vitamin D (yet again)
Also, Vitamin D appears to reduce or eliminate the cytokine storms

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Aggressive inflammatory response leading to hypercoagulability has been found to be associated with disease severity in COVID-19 patients and portends bad treatment outcome. A state of acute disseminated intravascular coagulation (DIC), along with pulmonary embolism and/or deep vein thrombosis, has been observed in critically ill ICU patients. Autopsy reports of COVID-19 patients demonstrated microthrombi in lungs and in other organs, as well as marked inflammatory changes, characteristic clinicopathological features that exacerbate disease severity. Vitamin D supplementation was recommended by many clinicians across the globe to improve clinical symptoms of COVID-19 patients, mainly because of its immunomodulatory roles on immune cells. Furthermore, vitamin D and its associated molecules are also known to directly or indirectly regulate various thrombotic pathways.
We propose that vitamin D supplementation not only attenuates the risk of Acute Respiratory Disease Syndrome (ARDS) but it also may have a role in reducing coagulation abnormalities in critically ill COVID-19 patients. The overarching goal of this review is to discuss the effects of vitamin D on coagulation pathways and other intertwined processes leading to thrombosis. Many clinical trials are currently investigating the efficacy of vitamin D supplementation in reducing the risk of COVID-19 infection. However, randomized placebo control clinical trials are also necessary to ascertain the effect of vitamin D supplementation on reducing the risk of coagulopathy in COVID-19 patients.


Created by admin. Last Modification: Saturday February 20, 2021 17:31:52 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
15077 Thromsosis studies.jpg admin 20 Feb, 2021 82.57 Kb 389
15076 clot.pdf admin 20 Feb, 2021 573.61 Kb 255