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Vitamin D fights many health problems – an umbrella review of 508 studies – July 2022


Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies

Advances in Nutrition, Vol 13, #4, July 2022, Pages 1044–1062, https://doi.org/10.1093/advances/nmab142
Di Liu, Xiaoni Meng, Qiuyue Tian, Weijie Cao, Xin Fan, Lijuan Wu, Manshu Song, Qun Meng, Wei Wang, Youxin Wang
 Download the PDF from VitaminDWiki

Consistency between Meta-analyses of observed and MR

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Meta-analyses of Observed and RCT

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Details of Meta-analyses of Observed and RCT

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Observational studies, randomized controlled trials (RCTs), and Mendelian randomization (MR) studies have yielded inconsistent results on the associations of vitamin D concentrations with multiple health outcomes. In the present umbrella review we aimed to evaluate the effects of low vitamin D concentrations and vitamin D supplementation on multiple health outcomes. We summarized current evidence obtained from meta-analyses of observational studies that examined associations between vitamin D concentrations and multiple health outcomes, meta-analyses of RCTs that investigated the effect of vitamin D supplementation on multiple health outcomes, and MR studies that explored the causal associations of vitamin D concentrations with various diseases (international prospective register of systematic reviews PROSPERO registration number CRD42018091434).
A total of

  • 296 meta-analyses of observational studies
    • comprising 111 unique outcomes,
  • 139 meta-analyses of RCTs
    • comprising 46 unique outcomes, and
  • 73 MR studies
    • comprising 43 unique outcomes

were included in the present umbrella review.
Twenty-eight disease outcomes were identified by both meta-analyses of observational studies and MR studies.
Seventeen of these reported disease outcomes had consistent results, demonstrating that lower concentrations of vitamin D were associated with a higher risk for all-cause mortality,

  • Alzheimer's disease,
  • hypertension,
  • schizophrenia, and
  • type 2 diabetes.

The combinations of consistent evidence obtained by meta-analyses of observational studies and MR studies together with meta-analyses of RCTs showed that vitamin D supplementation was associated with a decreased risk for all-cause mortality but not associated with the risk for Alzheimer's disease, hypertension, schizophrenia, or type 2 diabetes.
The results indicated that vitamin D supplementation is a promising strategy with long-term preventive effects on multiple chronic diseases and thus has the potential to decrease all-cause mortality. However, the current vitamin D supplementation strategy might not be an efficient intervention approach for these diseases, suggesting that new strategies are highly needed to improve the intervention outcomes.


641 Meta-analyses in VitaminDWiki (most are for Vitamin D trials)


VitaminDWiki - Proof that Vitamin D Works


Created by admin. Last Modification: Wednesday December 13, 2023 16:24:13 GMT-0000 by admin. (Version 23)

Attached files

ID Name Comment Uploaded Size Downloads
19593 Umbrella 2022_CompressPdf.pdf admin 25 May, 2023 499.80 Kb 78
18230 Meta details.jpg admin 02 Aug, 2022 240.42 Kb 267
18229 Observed and RCT.jpg admin 02 Aug, 2022 71.88 Kb 341
18228 Consistancy.jpg admin 02 Aug, 2022 79.97 Kb 375