Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men.
Int J Endocrinol. 2014;2014:543783. doi: 10.1155/2014/543783. Epub 2014 Apr 13.
Wang Y, Wang YJ, Zhan JK, Tang ZY, Huang W, Tan P, Gao S, Ma CL, Jian ZJ, Liu YS.
Geriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Vitamin D binding protein (DBP) may alter the biologic activity of 25-hydroxyvitamin D [25(OH)D]. The objective of our present study was to determine the joint effect of serum 25(OH)D and DBP on the risk of frailty. Five hundred sixteen male participants aged 70 years or older were recruited in Changsha city and its surrounding area in Hunan province of China. Frailty was defined as the presence of at least three of the five following criteria: weakness, low physical activity, slow walking speed, exhaustion, and weight loss. Multivariate linear regression analysis was performed to assess the relationship between 25(OH)D and DBP levels. Odds ratios (ORs) for frailty were evaluated across quartiles of 25(OH)D and DBP levels, adjusted age, education, and body mass index. The results showed that participants in the
- lowest quartile of 25(OH)D and the highest quartile of DBP levels, the
- lowest quartile of 25(OH)D and the lowest quartile of DBP levels, and those in the
- lower quartile of 25(OH)D and lowest quartile of DBP levels
had significantly higher OR of being frail compared with those in the highest quartile of 25(OH)D and lowest quartile of DBP, with OR of 3.18 (95% CI: 1.46-4.56, P < 0.05), 2.63 (95% CI: 1.31-3.68, P < 0.01), and 2.52 (95% CI: 1.22-3.52, P < 0.05), respectively. The results indicate that the joint effect of serum 25(OH)D and DBP levels is associated with the risk of frailty, and serum DBP levels affects 25(OH)D-frailty relationship in the older men.
PMID: 24822065
Summary by VitaminDWiki – compared to D >23 ng and low DBP
| Vitamin D level | DBP level | Frailty |
| < 13 g | Highest DBP | 3.2 X more likely |
| < 13 ng | Low DBP | 2.6 X more likely |
| 13-17 ng | Low DBP | 2.5X more likely |
See also VitaminDWiki
- Vitamin D tests assume constant Binding Protein - not correct across races and clinical situations – July 2014
- Hypothesis: Vitamin D Binding Protein limits vitamin D benefits outside of kidney too– Oct 2013
- Blacks have lower vitamin D levels, but OK active vitamin D levels (VDBP) - Feb 2015
- Vitamin D reduced so low that Victorian age diseases are returning has the following chart