Short-term UVB irradiation significantly increases vitamin D serum concentration in obese patients: a clinical pilot study
Endocrine, pp 1–10, Online: 10 Feb 2017, DOI: 10.1007/s12020-017-1252-2
Alexander Obbarius, BergerAndreas StengelCarmen GarciaFelix FischerTobias HofmannMatthias RoseRalf Uebelhack
The following disagrees with the study on this page, finding that response to UVB DECREASES with higher BMI
Size of the exposed body surface area, skin erythema and body mass index predict skin production of vitamin D. Aug 2015
- Normal weight Obese (50 ng = 125 nanomole)
Deficiency of vitamin D is very common in obese people and treatment by oral supplementation is not effective in all patients. This exploratory pilot study investigated the influence of different doses of short-term ultraviolet B irradiation on serum 25-hydroxyvitamin-D3 (25D) and 1,25-dihydroxyvitamin-D3 (1,25D) levels in obese compared to normal weight subjects and obese controls.
Participants with skin types II and III (Fitzpatrick skin classification) were assigned to six groups including four intervention groups receiving irradiation (three groups of obese and one group of normal weight subjects) and two control groups without treatment (obese and normal weight). Intervention groups received three sessions of whole body UVB irradiation of three different doses (cumulative doses over three sessions: 0.28, 0.70, 1.75 minimal erythema dose) within 1 week of intervention. Serum 25D and 1,25D were measured at baseline and after irradiation. Outcome differences between groups were analyzed using a linear model.
Serum 25D levels increased significantly in obese (+23.6 and +26.7%, respectively, p = 0.01) and normal weight (+15.6%, p = 0.02) intervention groups who received medium and high doses of ultraviolet B irradiation compared to control groups (+3.5 and −4.0%, respectively, p = 1.0). The increase in obese patients was 51.4% greater compared to normal weight controls irradiated with equal ultraviolet B doses. Low-level ultraviolet irradiation did not result in a significant change in serum 25D (+7.0%, p = 0.61). We did not detect any significant differences of 1,25D between groups (p = 0.25).
The current study indicates that short-term ultraviolet B irradiation increases 25D levels in obese patients.