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Perimenopause symptoms (climacteric syndrome) substantially reduced by 4 weeks of Magnesium – Sept 2017

Impact of magnesium deficiency on the course of climacteric syndrome

Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (6): 118-26. (in Russian)

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Makatsaria A.D., Dikke G.B.
1I.M. Sechenov First Moscow State Medical University, Moscow 119992, Malaya Trubetskaya str. 8 bld. 2, Russia
2Peoples’ Friendship University of Russia, Moscow 117198, Miklukho-Maklaya str. 8, Russia
Objective. To estimate the prevalence of magnesium deficiency (MD) and the characteristics of clinical symptoms in women with climacteric syndrome (CS) and to determine the efficacy of Magne B6 forte in improving the quality of life in patients.

Subjects and methods. A total of 3808 women with climacteric syndrome were examined. In the first phase of the study, the symptoms of CS and the prevalence of MD were assessed using the standardized Mood Disorder Questionnaire (MDQ) and/or serum magnesium levels were measured. The quality of life in the women with CS was estimated according to the WHOQOL-BREF questionnaire. In the second step, the patients with MD were treated with a magnesium citrate-containing drug for 4 weeks; the therapeutic efficiency was evaluated.

Results. The high prevalence of MD was noted in the patients with CS (60%). The clinical efficacy of Magne B,6 forte was confirmed by an

  • increase in serum magnesium levels (from 0.67±0.09 to 0.80±0.25 mmol/l; p < 0.001),
  • normalization of MDQ scores (from 43.4±11.9 to 24.0±14.9; p < 0.001),
  • a reduction in the severity of more than half of the CS symptoms by 2-2.5 times and
  • an improvement in quality of life.

Conclusion. The use of Magne B6 forte in patients with CS contributes to improvements in the course of the disease and in the quality of life.


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