Environ Int. 2013 Jul;57-58:34-41. doi: 10.1016/j.envint.2013.03.011. Epub 2013 May 4.
Morales E emorales1 at creal.cat, Gascon M, Martinez D, Casas M, Ballester F, Rodríguez-Bernal CL, Ibarluzea J, Marina LS, Espada M, Goñi F, Vizcaino E, Grimalt JO, Sunyer J; INMA Project.
Centre for Research in Environmental Epidemiology CREAL, Barcelona, Catalonia, Spain. emorales1 at creal.cat
Persistent organic pollutants (POPs) are suggested to contribute to lower vitamin D levels; however, studies in humans are scarce and have never focused on pregnancy, a susceptibility period for vitamin D deficiency.
We investigated whether serum levels of POPs were associated with circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration in pregnancy.
Cross-sectional associations of serum concentrations of eight POPs with plasma 25(OH)D3 concentration were analyzed in 2031 pregnant women participating in the Spanish population-based cohort INfancia y Medio Ambiente (INMA) Project. Serum concentrations of POPs were measured by gas chromatography and plasma 25(OH)D3 concentration was measured by high-performance liquid chromatography in pregnancy (mean 13.3±1.5weeks of gestation). Multivariable regression models were performed to assess the relationship between blood concentrations of POPs and 25(OH)D3.
An inverse linear relationship was found between serum concentration of PCB180 and circulating 25(OH)D3.
Multivariate linear regression models showed higher PCB180 levels to be associated with lower 25(OH)D3 concentration:
- quartile Q4 vs. quartile Q1, coefficient=-1.59, 95% CI -3.27, 0.08, p trend=0.060.
A non-monotonic inverse relationship was found between the sum of predominant PCB congeners (PCB 180, 153 and 138) and 25(OH)D3 concentration: coefficient (95% CI) for
- quartile Q2 vs. Q1 [-0.50 (-1.94, 0.94)],
- quartile Q3 vs. Q1 [-1.56 (-3.11, -0.02)] and
- quartile Q4 vs. Q1 [-1.21 (-2.80, 0.38)], p trend=0.081.
No significant associations were found between circulating 25(OH)D3 and serum levels of p,p'-DDE, p,p'-DDT, HCB, and ß-HCH.
Our results suggest that the background exposure to PCBs may result in lower 25(OH)D3 concentration in pregnant women.
- Pregnancy is a susceptibility period for vitamin D deficiency.
- We studied exposure to POPs as a cause of vitamin D deficiency in pregnant women.
- PCB background exposure was related to lower 25(OH)D3 concentration in pregnancy.
- Efforts to reduce body burden of POPs could improve vitamin D status in pregnancy.
PDF is available free at Sci-Hub 10.1016/j.envint.2013.03.011
- Increase of plastic compounds (phthalates) in urine during pregnancy associated with decreased Vitamin D – Aug 2017
- DDT and other pesticides decrease vitamin D – Jan 2012
Note: this web page is the same study as at PCBs increased the chance of being Vitamin D deficient by 3 percent – May 2013