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No reduction in Breast Cancer when vitamin D less than 40 ng - May 2011

Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II

A Heather Eliassen , Donna Spiegelman , Bruce W Hollis , Ronald L Horst , Walter C Willett and Susan E Hankinson
Breast Cancer Research 2011, 13:R50doi:10.1186/bcr2880
Volume 13, Issue 3, 11 May 2011

Introduction
Experimental evidence indicates vitamin D may play an important role in breast cancer etiology but epidemiologic evidence to date is inconsistent. Vitamin D comes from dietary intake and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure of vitamin D status.

Methods
We conducted a prospective nested case-control study within the Nurses' Health Study II (NHSII). Plasma samples collected in 1996-1999 were assayed for 25(OH)D in 613 cases, diagnosed after blood collection and before June 1, 2007, and 1218 matched controls. Multivariate relative risks (RR) and 95% confidence intervals (CI) were calculated by conditional logistic regression, adjusting for several breast cancer risk factors.

Results
No significant association was observed between plasma 25(OH)D levels and breast cancer risk (top vs. bottom quartile multivariate RR = 1.20, 95% CI (0.88-1.63), P- value, test for trend = 0.32). Results were similar when season-specific quartile cut points were used. Results did not change when restricted to women who were premenopausal at blood collection or premenopausal at diagnosis. Results were similar between estrogen receptor (ER)+/progesterone receptor (PR)+ and ER-/PR- tumors (P-value, test for heterogeneity = 0.51). The association did not vary by age at blood collection or season of blood collection, but did vary when stratified by body mass index (P-value, test for heterogeneity = 0.01).

Conclusions
Circulating 25(OH)D levels were not significantly associated with breast cancer risk in this predominantly premenopausal population.

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The study did not appear to consider a high enough level of vitamin D to make a difference

The top of their 4 bands started at 30 ng/ml.

There were probably not enough nurses with vitamin D levels > 40 ng to be statistically significant.

The following graph shows that vitamin D does not decrease breast cancer much for levels less than 40 ng/ml

Disease Incidence chart Lahore

See also VitaminDWiki

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