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More postpartum infections if low vitamin D (in winter) - Dec 2019

Vitamin D deficiency at the time of delivery – Prevalence and risk of postpartum infections

PLOS x https://doi.org/10.1371/journal.pone.0226673
Daniel Axelsson, Jan Brynhildsen, Marie Blomberg

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Histogram of total infections across all levels of vitamin D
(this is not % of infections @ each level of vitamin D)

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% with < 20 ng of vitamin D at time of birth

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Background
Postpartum infections are a common cause of morbidity after childbirth. Vitamin D deficiency has been shown to increase the risk for several infections in a non-pregnant population. Vitamin D deficiency has been described as common in pregnant women.

Objective
To investigate whether vitamin D deficiency in pregnant women in labor was associated with an increased risk of overall postpartum infectious morbidity within eight weeks of delivery. A secondary aim was to estimate the prevalence of vitamin D deficiency among pregnant women in Linköping, Sweden at the time of delivery.

Material and methods
Serum vitamin D levels in labor were analyzed for 1397 women. Vitamin D deficiency was defined as serum levels <50 nmol/L. All ICD-10 codes given to the women eight weeks postpartum were reviewed and postpartum infections were defined as the presence of an ICD-10 code suggestive of infection. The prevalence of postpartum infections among women with sufficient vitamin D levels was compared with women with vitamin D deficiency. Adjusted Odds Ratios and 95% confidence intervals for postpartum infections were calculated using multivariate logistic regression analysis.

Results
Fifty eight per cent of the women had serum vitamin D levels <50 nmol/L. The proportion of women with vitamin D deficiency varied, as expected, with season. No association between vitamin D deficiency and postpartum infections was found. For vitamin D 25–50 nmol/L the adjusted Odds Ratio was 0.85 (95% confidence interval 0.56–1.29) and for vitamin D <25 nmol/L the adjusted Odds Ratio was 1.15 (95% confidence interval 0.66–2.03). Women who smoked or who had a cesarean section had an increased risk of postpartum infections.

Conclusions
Vitamin D deficiency was more common than previously reported in Swedish pregnant women. No association between vitamin D deficiency and postpartum infections was found. Other well-known risk factors for postpartum infection were identified.


Created by admin. Last Modification: Friday December 20, 2019 00:02:30 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
13194 Deficiency vs month.jpg admin 19 Dec, 2019 23:39 50.32 Kb 313
13193 Infection.jpg admin 19 Dec, 2019 23:39 27.14 Kb 320
13192 postpartum infections.pdf PDF 2019 admin 19 Dec, 2019 23:38 1.09 Mb 304
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