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Low Vitamin D increased chance of COVID-19, unless supplement – May 13, 2020

Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence

David O Meltzer dmeltzer at medicine.bsd.uchicago.edu, Thomas J Best, Hui Zhang, Tamara Vokes, Vineet Arora, Julian Solway
doi: https://doi.org/10.1101/2020.05.08.20095893
''This article is a preprint and has not been certified by peer review.
It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.''

Supplement reduce COVID positive VDW#11767
Data for the chart comes from table 4
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VitaminDWiki

Overvational study of mainly health-care workers in Chicago
Vitamin D levels were tested sometime in the year before being tested for COVID-19
Those whom most-supplemented with vitamin D were far less likely to test positive

Suspect 6X less likely to test positive if taking 10,000 IU for >3 months
Suspect 15X less likely to test positive if take a single dose of vitamin D (cost 4 cents) a few weeks before

Note: A RCT is starting in Sri Lanka in June 2020 to see if the suspection is correct

 Download the PDF from VitaminDWiki

Importance: Vitamin D treatment has been found to decrease incidence of viral respiratory tract infection, especially in vitamin D deficiency. It is unknown whether COVID-19 incidence is associated with vitamin D deficiency and treatment.

Objective: To examine whether vitamin D deficiency and treatment are associated with testing positive for COVID-19. Design: Retrospective cohort study Setting: University of Chicago Medicine Participants: Patients tested for COVID-19 from 3/3/2020-4/10/2020. Vitamin D deficiency was defined by the most recent 25-hydroxycholecalciferol <20ng/ml or 1,25-dihydroxycholecalciferol <18pg/ml within 1 year before COVID-19 testing. Treatment was defined by the most recent vitamin D type and dose, and treatment changes between the time of the most recent vitamin D level and time of COVID-19 testing. Vitamin D deficiency and treatment changes were combined to categorize vitamin D status at the time of COVID-19 testing as likely deficient(last-level-deficient/treatment-not-increased), likely sufficient(last-level-not-deficient/treatment-not-decreased), or uncertain deficiency(last-level-deficient/treatment-increased or last-level-not-deficient/treatment-decreased).

Main Outcomes and Measures: The main outcome was testing positive for COVID-19. Multivariable analysis tested whether the most recent vitamin D level and treatment changes after that level were associated with testing positive for COVID-19 controlling for demographic and comorbidity indicators. Bivariate analyses of associations of treatment with vitamin D deficiency and COVID-19 were performed.

Results: Among 4,314 patients tested for COVID-19, 499 had a vitamin D level in the year before testing. Vitamin D status at the time of COVID-19 testing was categorized as likely deficient for 127(25%) patients, likely sufficient for 291(58%) patients, and uncertain for 81(16%) patients. In multivariate analysis, testing positive for COVID-19 was associated with increasing age (RR(age<50)=1.05, p<0.021; RR(age≥50)=1.02,p<0.064)), non-white race(RR=2.54,p<0.01) and being likely vitamin D deficient (deficient/treatment-not-increased: RR=1.77,p<0.02) as compared to likely vitamin D sufficient(not-deficient/treatment-not-decreased), with predicted COVID-19 rates in the vitamin D deficient group of 21.6%(95%CI[14.0%-29.2%] ) versus 12.2%(95%CI[8.9%-15.4%]) in the vitamin D sufficient group. Vitamin D deficiency declined with increasing vitamin D dose, especially of vitamin D3. Vitamin D dose was not significantly associated with testing positive for COVID-19.

Conclusions and Relevance: Vitamin D deficiency that is not sufficiently treated is associated with COVID-19 risk. Testing and treatment for vitamin D deficiency to address COVID-19 warrant aggressive pursuit and study.


COVID-19 treated by Vitamin D - studies, reports, videos - automatically updated


Facebook has a COVID-19 and Vitamin D page - medical professionals only
1400 members as of July 15, 2020

Intervention Clinical Trials
Intervention Trial Summary Table
COVID-19 RCTs

Observational

Vitamin D Dosing Recommendations for COVID-19

Some people wanted improved immune systems, so took more vitamin D

COVID-19 associated with Low Vitamin D

Vitamin D levels are lower in those who test positive for COVID-19 -[doi:10.3390/nu12051359| Nutrients] May 09

    • Image
  • [https://articles.mercola.com/sites/articles/archive/2020/05/08/vitamin-d-level-correlated-to-covid19-outcomes.aspx?cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20200508Z1&et_cid=DM527863&et_rid=867359477 |Vitamin D Level Is Directly Correlated to COVID-19 Outcome] Mercola May 8
    • Overview of many studies and video by Ivor Cummins
  • [https://www.sciencedaily.com/releases/2020/05/200507131012.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fvitamin_d+%28Vitamin+D+News+--+ScienceDaily%29 |Vitamin D linked to low virus death rate in 20 countries in Europe] Science Daily May 7
  • [https://doi.org/10.1101/2020.05.01.20087965 |Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes] May 6 preprint
    • Excellent extensive use of Causal Influence AI to discover associations.
    • I have suspected that Causal Influence could be much better, far lower cost, and faster than the use of RCTs
  • [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3586555|Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 deaths] preprint May 7
    • "permanent unit increase in UVI is associated with a 2.2 % decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01]
    • as well as a 1.9 % decline in the daily growth rates of CFR [p < 0.05]
    • 64 countries, 78 days, 6 UVI models
  • [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3593258#.XrE0oF1wSjU.twitter |Vitamin D Level of Mild and Severe Elderly Cases of COVID-19: A Preliminary Report] May 5
    • 176 seniors in S. Asia - published in India
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  • Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020
  • COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020
  • COVID-19 was 19X more likely if low vitamin D (may be invalid data)– April 2020 Philippines
    • The raw data has strange gaps in the vitamin D levels
    • Image
  • Research Suggests a Link Between Vitamin D Deficiency and COVID-19 Deaths May 5
  • Indonesia preprint 13X if vitamin D insufficient,19X for patients who are vitamin D deficient.
    • VitaminDWiki has requested but has not yet access to the raw data
  • COVID-19 infections associated with very low vitamin D – Turin Italy – March 2020

Speculation

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Higher levels of vitamin D result in fewer COVID-19 problems

VIDEOS and PODCASTS


Search Google Scholar for "COVID-19" "Vitamin D"
17,200 publications as of July 1, 2020


Groups which ignore Vitamin D possibility

  • The Wellcome-Gates COVID-19 Accelerator initiative expressly prohibits funding for Vitamins.

Why/How Vitamin D both treats and prevents virus

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Short URL for this section = is.gd/COVIDMedia


VitaminDWiki: 25 most-recently changed VIRUS pages (Coronavirus)

Id Page Hits Last modification Creator Categories
11728 COVID-19 treated by Vitamin D - studies, reports, videos 7344
03 Aug, 2020 16:52
admin Virus
11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 248403
03 Aug, 2020 07:46
admin Virus
11878 Vitamin C IV, which treats Sepsis, also treats COVID-19 - May 2020 22
01 Aug, 2020 11:58
admin Virus
11870 Call to Action: Eliminate Vitamin D Deficiency during COVID-19 (7 reasons) – Manson July 23, 2020 116
28 Jul, 2020 19:54
admin Consensus
Virus
11867 Low Vitamin D Levels Worsen COVID-19: Facts and Imperatives - Pfleger July 2020 109
27 Jul, 2020 12:28
admin Virus
11865 Health problems at high risk of COVID-19 142
27 Jul, 2020 11:16
admin Virus
10059 Cerebral malaria deaths prevented by loading dose of vitamin D (mice) – Sept 2018 650
25 Jul, 2020 02:39
admin Loading dose for Vitamin D
Virus
11218 Infections and low vitamin D (including deep neck infections) 2197
24 Jul, 2020 11:59
admin Immunity
Inflammation
Virus
11727 COVID-19 more frequent and deadly for those with dark skins (high risk of low vitamin D) 2773
23 Jul, 2020 22:52
admin Skin - Dark
Virus
11749 COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020 992
22 Jul, 2020 20:25
admin Virus
11823 COVID-19 deaths strongly correlated with percent having less than 10 ng of Vitamin D in a country– July 1 2020 336
22 Jul, 2020 20:24
admin Virus
11850 Massive Review of papers on Vitamin D and COVID-19 - July 3, 2020 753
22 Jul, 2020 20:11
admin Top news
Virus
11795 COVID-19 resulted in 3.7X decrease in Irish Very Low Weight Births (Vitamin D) - June 2020 301
19 Jul, 2020 10:10
admin Pregnancy
Virus
11852 Vitamin D recommended for COVID-19 – yet another study – July 17, 2020 204
18 Jul, 2020 14:06
admin Virus
11846 Long-distance truck drivers more likely to get COVID-19 - July 2020 83
17 Jul, 2020 10:18
admin Virus
11821 Nursing homes could reduce risk of COVID-19 with Vitamin D – June 30, 2020 438
14 Jul, 2020 21:30
admin Seniors
High Risk
Shut-in
Virus
11842 COVID-19 antibodies mostly gone in 2 months (2 Chinese studies) – June 2020 183
14 Jul, 2020 20:30
admin Virus
11840 Covid-19, T cells, and Vitamin D 238
13 Jul, 2020 20:24
admin Immunity
Virus
11838 COVID-19 linked to low vitamin D in 6 of 7 PubMed studies (as of April) – June 2020 193
11 Jul, 2020 16:41
admin Virus
11837 COVID-19 might be treated with Mg IV and Potassium – July 2020 141
11 Jul, 2020 14:26
admin Vitamin D and Magnesium
Virus
11833 Vitamin D and COVID-19 - VitaminD3World - July 2020 198
07 Jul, 2020 17:35
admin Virus
11828 Risk of dying of COVID-19 was 3.7 X higher if less than 8 ng of VItamin D - Mexico May 2020 334
07 Jul, 2020 15:26
admin Virus
11827 ICU was 2X less likely for COVID-19 hospitalization if Vitamin D more than 20 ng – July 2020 190
06 Jul, 2020 11:09
admin Trauma and surgery
Virus
11766 Fight COVID-19 with Vitamin D, Vitamin C, Zinc, Selenium, Resveratrol, etc. - Sardi May 12, 2020 1006
05 Jul, 2020 16:46
admin Virus
Zinc
Resveratrol
11682 Reduce Coronavirus risk with Vitamin D (50,000 IU once a week) 6007
05 Jul, 2020 01:24
admin Virus


Created by admin. Last Modification: Saturday May 30, 2020 19:26:42 GMT-0000 by admin. (Version 19)

Attached files

ID Name Comment Uploaded Size Downloads
13817 Masterjohn May 15.pdf admin 15 May, 2020 11:26 62.53 Kb 33
13815 T4.jpg admin 15 May, 2020 01:50 44.34 Kb 545
13814 Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence.pdf PDF 2020 admin 15 May, 2020 01:49 872.30 Kb 105
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