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Low Vitamin D increased chance of COVID-19, unless supplement – May 13, 2020

Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence

David O Meltzer dmeltzer at medicine.bsd.uchicago.edu, Thomas J Best, Hui Zhang, Tamara Vokes, Vineet Arora, Julian Solway
doi: https://doi.org/10.1101/2020.05.08.20095893
''This article is a preprint and has not been certified by peer review.
It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.''

Supplement reduce COVID positive VDW#11767
Data for the chart comes from table 4


Overvational study of mainly health-care workers in Chicago
Vitamin D levels were tested sometime in the year before being tested for COVID-19
Those whom most-supplemented with vitamin D were far less likely to test positive

Suspect 6X less likely to test positive if taking 10,000 IU for >3 months
Suspect 15X less likely to test positive if take a single dose of vitamin D (cost 4 cents) a few weeks before

Note: A RCT is starting in Sri Lanka in May 2020 to see if the suspection is correct

 Download the PDF from VitaminDWiki

Importance: Vitamin D treatment has been found to decrease incidence of viral respiratory tract infection, especially in vitamin D deficiency. It is unknown whether COVID-19 incidence is associated with vitamin D deficiency and treatment.

Objective: To examine whether vitamin D deficiency and treatment are associated with testing positive for COVID-19. Design: Retrospective cohort study Setting: University of Chicago Medicine Participants: Patients tested for COVID-19 from 3/3/2020-4/10/2020. Vitamin D deficiency was defined by the most recent 25-hydroxycholecalciferol <20ng/ml or 1,25-dihydroxycholecalciferol <18pg/ml within 1 year before COVID-19 testing. Treatment was defined by the most recent vitamin D type and dose, and treatment changes between the time of the most recent vitamin D level and time of COVID-19 testing. Vitamin D deficiency and treatment changes were combined to categorize vitamin D status at the time of COVID-19 testing as likely deficient(last-level-deficient/treatment-not-increased), likely sufficient(last-level-not-deficient/treatment-not-decreased), or uncertain deficiency(last-level-deficient/treatment-increased or last-level-not-deficient/treatment-decreased).

Main Outcomes and Measures: The main outcome was testing positive for COVID-19. Multivariable analysis tested whether the most recent vitamin D level and treatment changes after that level were associated with testing positive for COVID-19 controlling for demographic and comorbidity indicators. Bivariate analyses of associations of treatment with vitamin D deficiency and COVID-19 were performed.

Results: Among 4,314 patients tested for COVID-19, 499 had a vitamin D level in the year before testing. Vitamin D status at the time of COVID-19 testing was categorized as likely deficient for 127(25%) patients, likely sufficient for 291(58%) patients, and uncertain for 81(16%) patients. In multivariate analysis, testing positive for COVID-19 was associated with increasing age (RR(age<50)=1.05, p<0.021; RR(age≥50)=1.02,p<0.064)), non-white race(RR=2.54,p<0.01) and being likely vitamin D deficient (deficient/treatment-not-increased: RR=1.77,p<0.02) as compared to likely vitamin D sufficient(not-deficient/treatment-not-decreased), with predicted COVID-19 rates in the vitamin D deficient group of 21.6%(95%CI[14.0%-29.2%] ) versus 12.2%(95%CI[8.9%-15.4%]) in the vitamin D sufficient group. Vitamin D deficiency declined with increasing vitamin D dose, especially of vitamin D3. Vitamin D dose was not significantly associated with testing positive for COVID-19.

Conclusions and Relevance: Vitamin D deficiency that is not sufficiently treated is associated with COVID-19 risk. Testing and treatment for vitamin D deficiency to address COVID-19 warrant aggressive pursuit and study.

COVID-19 treated by Vitamin D - studies, reports, videos - automatically updated

Intervention Clinical Trials

Observation Clinical Trials

Vitamin D Dosing Recommendations for COVID-19

COVID-19 associated with Low Vitamin D

Vitamin D levels are lower in those who test positive for COVID-19 - Nutrients May 09


Higher levels of vitamin D result in fewer COVID-19 problems


Search Google Scholar for "COVID-19" "Vitamin D"
2510 publications as of May 16, 2020
Short URL for this section = is.gd/COVIDMedia

VitaminDWiki: 25 most-recently changed VIRUS pages (Coronavirus)

Id Page Hits Last modification Creator Categories
11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 234030
29 May, 2020 20:26
admin Virus
11728 COVID-19 treated by Vitamin D - studies, reports, videos 3667
29 May, 2020 15:11
admin Virus
11727 COVID-19 more frequent and deadly for those with dark skins (high risk of low vitamin D) 1593
29 May, 2020 13:53
admin Skin - Dark
11777 COVID-19 associated with low Vitamin D in more than 20 studies – May 21, 2020 405
22 May, 2020 13:58
admin Virus
11776 Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21... 233
21 May, 2020 19:14
admin Vitamin D Receptor
11609 Coronaviruses attach to cells via ACE2, Vitamin D might reduce ACE2 27331
21 May, 2020 12:09
admin Virus
11596 Dr. Coimbra on Coronavirus and Vitamin D (English transcript) - Jan 2020 2506
21 May, 2020 11:15
admin Virus
11767 Low Vitamin D increased chance of COVID-19, unless supplement – May 13, 2020 493
21 May, 2020 11:15
admin Virus
11775 High Vitamin D may prevent or treat COVID-19 - April 23, 2020 196
21 May, 2020 11:07
admin Virus
6630 Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015 11305
20 May, 2020 16:57
admin Intervention
Vitamin D in Canada
11771 Vitamin D trial with COVID-19 in Sri Lanka - interview May 16 231
18 May, 2020 18:39
admin Virus
11765 There are 2 concurrent pandemics – COVID-19 and Vitamin D deficiency – May 13, 2020 437
14 May, 2020 13:26
admin Virus
11763 COVID-19 might be prevented in 2 months by 50,000 IU weekly – May 12, 2020 480
12 May, 2020 14:23
admin Virus
11761 COVID-19 and high-dose Vitamin D - Video interview of Dr. Coimbra- May 1 404
10 May, 2020 01:43
admin Books, videos on Vitamin D
11760 UK makes a U-turn on Vitamin D and COVID-19 - a vivid imagination 804
09 May, 2020 20:54
admin Virus
7304 Dengue virus 2X to 4X more likely if vitamin D receptor gene problems 2047
08 May, 2020 10:53
admin Vitamin D Receptor
11730 Poop could save cities from too-early lockdown release 665
02 May, 2020 17:02
admin Virus
11753 More Vitamin K associated with fewer COVID-19 problems - April 25, 2020 533
30 Apr, 2020 11:37
admin Vitamin D and Vitamin K
11749 COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020 635
29 Apr, 2020 22:29
admin Virus
11736 Critical COVID-19 was 19X more likely if low vitamin D – April 15, 2020 4958
29 Apr, 2020 14:20
admin Virus
11745 COVID-19 is harder for those with dark skins - perhaps due to low vitamin D – April 24, 2020 461
28 Apr, 2020 16:15
admin Skin - Dark
11710 Indications of increase COVID-19 problems if dark skin in the UK- April 3 2020 607
25 Apr, 2020 12:46
admin Skin - Dark
11741 Towards a COVID-19 vaccine - France April 14,2020 299
21 Apr, 2020 14:42
admin Virus
11740 COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020 1023
21 Apr, 2020 12:16
admin Mortality and D
11702 Clear Association between Influenza and low Vitamin D - March 2020 772
20 Apr, 2020 16:55
admin Immunity

Created by admin. Last Modification: Thursday May 21, 2020 11:15:00 GMT-0000 by admin. (Version 18)

Attached files

ID Name Comment Uploaded Size Downloads
13817 Masterjohn May 15.pdf admin 15 May, 2020 11:26 62.53 Kb 20
13815 T4.jpg admin 15 May, 2020 01:50 44.34 Kb 341
13814 Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence.pdf PDF 2020 admin 15 May, 2020 01:49 872.30 Kb 45
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