Low Vitamin D increased chance of COVID-19, unless supplement – May 13, 2020

Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence

David O Meltzer dmeltzer@medicine.bsd.uchicago.edu, Thomas J Best, Hui Zhang, Tamara Vokes, Vineet Arora, Julian Solway
doi: https://doi.org/10.1101/2020.05.08.20095893
''This article is a preprint and has not been certified by peer review.
It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.''

Supplement reduce COVID positive VDW#11767
Data for the chart comes from table 4
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VitaminDWiki

Overvational study of mainly health-care workers in Chicago
Vitamin D levels were tested sometime in the year before being tested for COVID-19
Those whom most-supplemented with vitamin D were far less likely to test positive

Suspect 6X less likely to test positive if taking 10,000 IU for >3 months
Suspect 15X less likely to test positive if take a single dose of vitamin D (cost 4 cents) a few weeks before

Note: A RCT is starting in Sri Lanka in June 2020 to see if the suspection is correct

 Download the PDF from VitaminDWiki

Importance: Vitamin D treatment has been found to decrease incidence of viral respiratory tract infection, especially in vitamin D deficiency. It is unknown whether COVID-19 incidence is associated with vitamin D deficiency and treatment.

Objective: To examine whether vitamin D deficiency and treatment are associated with testing positive for COVID-19. Design: Retrospective cohort study Setting: University of Chicago Medicine Participants: Patients tested for COVID-19 from 3/3/2020-4/10/2020. Vitamin D deficiency was defined by the most recent 25-hydroxycholecalciferol <20ng/ml or 1,25-dihydroxycholecalciferol <18pg/ml within 1 year before COVID-19 testing. Treatment was defined by the most recent vitamin D type and dose, and treatment changes between the time of the most recent vitamin D level and time of COVID-19 testing. Vitamin D deficiency and treatment changes were combined to categorize vitamin D status at the time of COVID-19 testing as likely deficient(last-level-deficient/treatment-not-increased), likely sufficient(last-level-not-deficient/treatment-not-decreased), or uncertain deficiency(last-level-deficient/treatment-increased or last-level-not-deficient/treatment-decreased).

Main Outcomes and Measures: The main outcome was testing positive for COVID-19. Multivariable analysis tested whether the most recent vitamin D level and treatment changes after that level were associated with testing positive for COVID-19 controlling for demographic and comorbidity indicators. Bivariate analyses of associations of treatment with vitamin D deficiency and COVID-19 were performed.

Results: Among 4,314 patients tested for COVID-19, 499 had a vitamin D level in the year before testing. Vitamin D status at the time of COVID-19 testing was categorized as likely deficient for 127(25%) patients, likely sufficient for 291(58%) patients, and uncertain for 81(16%) patients. In multivariate analysis, testing positive for COVID-19 was associated with increasing age (RR(age<50)=1.05, p<0.021; RR(age≥50)=1.02,p<0.064)), non-white race(RR=2.54,p<0.01) and being likely vitamin D deficient (deficient/treatment-not-increased: RR=1.77,p<0.02) as compared to likely vitamin D sufficient(not-deficient/treatment-not-decreased), with predicted COVID-19 rates in the vitamin D deficient group of 21.6%(95%CI[14.0%-29.2%] ) versus 12.2%(95%CI[8.9%-15.4%]) in the vitamin D sufficient group. Vitamin D deficiency declined with increasing vitamin D dose, especially of vitamin D3. Vitamin D dose was not significantly associated with testing positive for COVID-19.

Conclusions and Relevance: Vitamin D deficiency that is not sufficiently treated is associated with COVID-19 risk. Testing and treatment for vitamin D deficiency to address COVID-19 warrant aggressive pursuit and study.


COVID-19 treated by Vitamin D - studies, reports, videos - automatically updated


Facebook has a COVID-19 and Vitamin D page - invitation only
1200 members as of July 5, 2020
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Intervention Clinical Trials
Intervention Trial Summary Checked July 8
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Observational Clinical Trials

Vitamin D Dosing Recommendations for COVID-19

  • Portion of image from June 5 video (below)
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  • Commentary: Myths and facts on vitamin D amidst the COVID-19 pandemic Metabolism, June 2, FREE PDF, peer-reviewed publication
    • "Preventive doses of vitamin D3 of 10,000 IU/day for 4 weeks followed by 5000 IU/day to reach a target 25(OH)D level of 100–150 nmol/L [24], and treatment doses >6000 IU/day in deficient individuals to reach a similar level and reduce disease progression [48], are suggested. ""
    • Comment: Strange that the treatment dose is less than the prevention dose. Note treatment dose will take > 3 months to help
      • Perhaps they meant the treatment dose to be 60,000 IU, not 6,000 IU
  • Perspective: improving vitamin D status in the management of COVID-19 May 22 free PDF
    • If low: 50,000 IU twice a week at the diagnosis (100,000 IU total)., then 50,000 IU taken once a week for the 2nd and 3rd weeks.
      • Note: VitaminDWiki believes that this dosing is not large enough for prevention, much less treatment
  • COVID-19 might be prevented in 2 months by 50,000 IU weekly – May 12, 2020
  • for people who have not been taking any vitamin D BusinessWorld May 22 - by Dr Renu Mahtani in videos below
    • Vitamin D 60k IU twice a week for two weeks to be followed by 60k once a week for the next six weeks.
    • or Vitamin D 60k IU daily for three days to be followed by 60k weekly for the total period of two months.
    • Thus 480,000 IU total, No Vitamin D testing needed

Some people wanted improved immune systems, so took more vitamin D

COVID-19 associated with Low Vitamin D

Vitamin D levels are lower in those who test positive for COVID-19 -[doi:10.3390/nu12051359| Nutrients] May 09

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  • [https://articles.mercola.com/sites/articles/archive/2020/05/08/vitamin-d-level-correlated-to-covid19-outcomes.aspx?cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20200508Z1&et_cid=DM527863&et_rid=867359477 |Vitamin D Level Is Directly Correlated to COVID-19 Outcome] Mercola May 8
    • Overview of many studies and video by Ivor Cummins
  • [https://www.sciencedaily.com/releases/2020/05/200507131012.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fvitamin_d+%28Vitamin+D+News+--+ScienceDaily%29 |Vitamin D linked to low virus death rate in 20 countries in Europe] Science Daily May 7
  • [https://doi.org/10.1101/2020.05.01.20087965 |Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes] May 6 preprint
    • Excellent extensive use of Causal Influence AI to discover associations.
    • I have suspected that Causal Influence could be much better, far lower cost, and faster than the use of RCTs
  • [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3586555|Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 deaths] preprint May 7
    • "permanent unit increase in UVI is associated with a 2.2 % decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01]
    • as well as a 1.9 % decline in the daily growth rates of CFR [p < 0.05]
    • 64 countries, 78 days, 6 UVI models
  • [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3593258#.XrE0oF1wSjU.twitter |Vitamin D Level of Mild and Severe Elderly Cases of COVID-19: A Preliminary Report] May 5
    • 176 seniors in S. Asia - published in India
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  • Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020
  • COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020
  • COVID-19 was 19X more likely if low vitamin D (may be invalid data)– April 2020 Philippines
    • The raw data has strange gaps in the vitamin D levels
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  • Research Suggests a Link Between Vitamin D Deficiency and COVID-19 Deaths May 5
  • Indonesia preprint 13X if vitamin D insufficient,19X for patients who are vitamin D deficient.
    • VitaminDWiki has requested but has not yet access to the raw data
  • COVID-19 infections associated with very low vitamin D – Turin Italy – March 2020

Speculation

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Higher levels of vitamin D result in fewer COVID-19 problems

VIDEOS and PODCASTS


Search Google Scholar for "COVID-19" "Vitamin D"
17,200 publications as of July 1, 2020


Groups which ignore Vitamin D possibility

  • The Wellcome-Gates COVID-19 Accelerator initiative expressly prohibits funding for Vitamins.


Short URL for this section = is.gd/COVIDMedia


VitaminDWiki: 25 most-recently changed VIRUS pages (Coronavirus)

Id Page Hits Last modification Creator Categories
11727 COVID-19 more frequent and deadly for those with dark skins (high risk of low vitamin D) 2380
12 Jul, 2020 14:00
admin Skin - Dark
Virus
11838 COVID-19 linked to low vitamin D in 6 of 7 PubMed studies (as of April) – June 2020 45
11 Jul, 2020 16:41
admin Virus
11728 COVID-19 treated by Vitamin D - studies, reports, videos 6202
11 Jul, 2020 16:40
admin Virus
11837 COVID-19 might be treated with Mg IV and Potassium – July 2020 33
11 Jul, 2020 14:26
admin Vitamin D and Magnesium
Virus
11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 244003
10 Jul, 2020 00:39
admin Virus
11833 Vitamin D and COVID-19 - VitaminD3World - July 2020 76
07 Jul, 2020 17:35
admin Virus
11828 Risk of dying of COVID-19 was 3.7 X higher if less than 8 ng of VItamin D - Mexico May 2020 199
07 Jul, 2020 15:26
admin Virus
11827 ICU was 2X less likely for COVID-19 hospitalization if Vitamin D more than 20 ng – July 2020 91
06 Jul, 2020 11:09
admin Trauma and surgery
Virus
11766 Fight COVID-19 with Vitamin D, Vitamin C, Zinc, Selenium, Resveratrol, etc. - Sardi May 12, 2020 855
05 Jul, 2020 16:46
admin Virus
Zinc
Resveratrol
11682 Reduce Coronavirus risk with Vitamin D (50,000 IU once a week) 5770
05 Jul, 2020 01:24
admin Virus
11823 COVID-19 deaths strongly correlated with percent having less than 10 ng of Vitamin D in a country– July 1 2020 125
04 Jul, 2020 19:49
admin Virus
11736 COVID-19 was 19X more likely if low vitamin D (may be invalid data)– April 2020 6124
04 Jul, 2020 14:17
admin Virus
11826 Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020 88
04 Jul, 2020 14:00
admin Vitamin D Receptor
Virus
11825 Respiratory viral infection (RSV) and low vitamin D – July 2020 126
03 Jul, 2020 16:22
admin Breathing
Infant-Child
Virus
3780 Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis, Ebola) – March 2011 39561
03 Jul, 2020 15:22
admin Virus
11821 Nursing homes could reduce risk of COVID-19 with Vitamin D – June 30, 2020 122
01 Jul, 2020 16:05
admin Seniors
High Risk
Shut-in
Virus
11819 Hill's Criteria indicates that COVID-19 will be treated by Vitamin D - Annweiler June 8 2020 214
30 Jun, 2020 01:18
admin Virus
11805 Mild COVID-19 quickly treated by Zinc lozenges in 4 people – June 6, 2020 274
29 Jun, 2020 16:37
admin Immunity
Virus
Zinc
11817 High-altitude Cusco, Peru has far lower rate of COVID-19 than others (high UVB and Vitamin D) - June 2020 152
28 Jun, 2020 03:05
admin Virus
2253 Flu vaccine effectiveness and side effects 11066
27 Jun, 2020 17:57
admin Virus
11813 How We can fix this pandemic in a month (Vitamin D: 20K IU for 14 days) – June 22, 2020 525
23 Jun, 2020 01:11
admin Virus
11776 Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21... 620
22 Jun, 2020 01:30
admin Vitamin D Receptor
Virus
11807 Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship – June 7, 2020 245
18 Jun, 2020 15:55
admin Virus
11799 Lockdown lunacy: The Thinking Person’s Guide – June 04, 2020 419
11 Jun, 2020 01:37
admin Virus
11798 The role of vitamin D in reducing risk of COVID-19: a brief survey of the literature - June 9, 2020 366
11 Jun, 2020 01:09
admin Virus

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