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Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017

Physiological serum 25-hydroxyvitamin D concentrations are associated with improved thyroid function — observations from a community-based program

Endocrine, pp 1–11, Online: 24 October 2017
Naghmeh Mirhosseini, Ludovic Brunel, Giovanna Muscogiuri, Samantha Kimbal

Reduction in Thyroid Symptoms in 3367 people achieving >50 ng level of Vitamin D


Even more reduction in people achieving >80 ng


 Download the PDF from VitaminDWiki

Purpose: Vitamin D deficiency has been associated with an increased risk of hypothyroidism and autoimmune thyroid disease. Our aim was to investigate the influence of vitamin D supplementation on thyroid function and anti-thyroid antibody levels.

Methods: We constructed a database that included 11,017 participants in a health and wellness program that provided vitamin D supplementation to target physiological serum 25-hydroxyvitamin D [25(OH)D] concentrations (>100 nmol/L). Participant measures were compared between entry to the program (baseline) and follow-up (12 ± 3 months later) using an intent-to-treat analysis. Further, a nested case-control design was utilized to examine differences in thyroid function over 1 year in hypothyroid individuals and euthyroid controls.

Results: More than 72% of participants achieved serum 25(OH)D concentrations >100 nmol/L at follow-up, with 20% above 125 nmol/L.
Hypothyroidism was detected in

  • 2% (23% including subclinical hypothyroidism) of participants at baseline and
  • 0.4% (or 6% with subclinical) at follow-up.

Serum 25(OH)D concentrations ≥125 nmol/L were associated with a

  • 30% reduced risk of hypothyroidism and a
  • 32% reduced risk of elevated anti-thyroid antibodies.

Hypothyroid cases were found to have higher mean serum 25(OH)D concentrations at follow-up, which was a significant positive predictor of improved thyroid function.

Conclusion: The results of the current study suggest that optimal thyroid function might require serum 25(OH)D concentrations above 125 nmol/L. Vitamin D supplementation may offer a safe and economical approach to improve thyroid function and may provide protection from developing thyroid disease

Clipped from PDF
  • 11,000 Canadians, Mean age was 48
  • "In Canada, one in ten suffer from a thyroid disorder, half of them undiagnosed”
  • “The present analysis utilized a large database of participants in a wellness program receiving vitamin D supplementation, with average doses of 6000 IU/d” (for 1 year)
  • “Approximately 2% of participants in this health and wellness program were found to be hypothyroid at program entry, with an additional 22% classified as subclinical hypothyroid.”
  • “ . . 15.8% of participants that reported thyroid medication use”
  • “ . . hypothyroid individuals were three times more likely (27%) and subclinical hypothyroidism nearly twice as likely (17%) to be vitamin D-deficient than euthyroid individuals (10%)”
  • “Most intriguing was the finding that subclinical hypothyroidism was reduced by 72% at follow-up.”

Chart of results by Grassrootshealth (GRH also sells TSH home test kit)


See also VitaminDWiki

6 Intervention Thyroid studies

This list is automatically updated

8+ VitaminDWiki pages with HASHIMOTO'S in title

This list is automatically updated

Items found: 8

Created by admin. Last Modification: Friday January 6, 2023 16:07:37 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
19067 Thyroid GRH.jpg admin 06 Jan, 2023 155.50 Kb 197
8596 Thyroid higher than 80 ng.jpg admin 27 Oct, 2017 26.28 Kb 1204
8595 Thyroid vs 50 ng.jpg admin 27 Oct, 2017 45.24 Kb 2669
8594 thyroid function.pdf admin 27 Oct, 2017 721.59 Kb 735