Physiological serum 25-hydroxyvitamin D concentrations are associated with improved thyroid function — observations from a community-based program
Endocrine, pp 1–11, Online: 24 October 2017
Naghmeh Mirhosseini, Ludovic Brunel, Giovanna Muscogiuri, Samantha Kimbal
- Thyroid problems more than double when both Vitamin D and Iodine are low – Sept 2017
Study on this page mentions vitamin B12 deficiency.
Wonder how big the increased benefit would be from high vitamain D + B12 + Iodine
- The Role of Vitamin D in Thyroid Diseases – Sept 2017
- Graves' disease and Hashimoto's thyroiditis 1.5X less likely for each 2 ng more vitamin D – Sept 2015
- Autoimmune Thyroid Disease 3X more likely if low vitamin D – meta-analysis April 2015
Purpose: Vitamin D deficiency has been associated with an increased risk of hypothyroidism and autoimmune thyroid disease. Our aim was to investigate the influence of vitamin D supplementation on thyroid function and anti-thyroid antibody levels.
Methods: We constructed a database that included 11,017 participants in a health and wellness program that provided vitamin D supplementation to target physiological serum 25-hydroxyvitmain D [25(OH)D] concentrations (>100 nmol/L). Participant measures were compared between entry to the program (baseline) and follow-up (12 ± 3 months later) using an intent-to-treat analysis. Further, a nested case-control design was utilized to examine differences in thyroid function over 1 year in hypothyroid individuals and euthyroid controls.
Results: More than 72% of participants achieved serum 25(OH)D concentrations >100 nmol/L at follow-up, with 20% above 125 nmol/L.
Hypothyroidism was detected in
- 2% (23% including subclinical hypothyroidism) of participants at baseline and
- 0.4% (or 6% with subclinical) at follow-up.
Serum 25(OH)D concentrations ≥125 nmol/L were associated with a
- 30% reduced risk of hypothyroidism and a
- 32% reduced risk of elevated anti-thyroid antibodies.
Hypothyroid cases were found to have higher mean serum 25(OH)D concentrations at follow-up, which was a significant positive predictor of improved thyroid function.
Conclusion: The results of the current study suggest that optimal thyroid function might require serum 25(OH)D concentrations above 125 nmol/L. Vitamin D supplementation may offer a safe and economical approach to improve thyroid function and may provide protection from developing thyroid disease
- 11,000 Canadians, Mean age was 48
- "In Canada, one in ten suffer from a thyroid disorder, half of them undiagnosed”
- “The present analysis utilized a large database of participants in a wellness program receiving vitamin D supplementation, with average doses of 6000 IU/d” (for 1 year)
- “Approximately 2% of participants in this health and wellness program were found to be hypothyroid at program entry, with an additional 22% classified as subclinical hypothyroid.”
- “ . . 15.8% of participants that reported thyroid medication use”
- “ . . hypothyroid individuals were three times more likely (27%) and subclinical hypothyroidism nearly twice as likely (17%) to be vitamin D-deficient than euthyroid individuals (10%)”
- “Most intriguing was the finding that subclinical hypothyroidism was reduced by 72% at follow-up.”