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Could growing pains in a child be a vitamin D deficiency – Sept 2010

Probably YES - but see also Magnesium

Is Your Child Suffering From "Growing Pains"?

News by The Pediatric Insider © 2010 Roy Benaroch, MD

Clipped out the following

Recent research has shown that vitamin D deficiency can contribute to night-time muscle and bone pains in some children. Parents of children with apparent growing pains may want to try a vitamin D supplement, 400 IU per day (that’s the usual concentration in most children’s vitamins.)

Other references on the internet

http://www.ped-rheum.com/content/5/1/5 Medical publication 2007
http://www.thevitamindcure.com/blog/?p=10 By Doctor Dowd author of the Vitamin D Cure
http://deliciouslivingmag.com/health/kids/1001-children-growing-pains/ Dr. Dowd again

A posted question about growing pains

answers included Calcium , vitamin deficiency, lack of vitamin D, too many clouds in the Pacific Northwest, Magnesium deficiency (which is related to vitamin D)

Wonder if 'growing pains' meets many of the criteria to indicate it is associated with vitamin D deficiency such as

  • more in winter
  • more when further from the equator
  • more if dark skin
  • more in cloudy areas

Note: As a child I had strong 'growing pains' living the Northern part of the US which has the most clouds = Western Washington

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94 percent of children with growing pains were low on vitamin D

Vitamin D levels in children with growing pains.

J Coll Physicians Surg Pak. 2011 May;21(5):284-7.
Qamar S, Akbani S, Shamim S, Khan G.
Department of Paediatrics, Liaquat National Medical College and Hospital, Karachi.

OBJECTIVE: To estimate the serum levels of vitamin D in children with growing pains and determine the relationship between serum vitamin D levels, parathormone and routine biochemical markers.

STUDY DESIGN: Cross-sectional study.

PLACE AND DURATION OF STUDY: Department of Paediatrics, Liaquat National Hospital, Karachi, from October 2008 to September 2009.

METHODOLOGY: Hundred children, aged 5-12 years presenting in Paediatric Outpatient Department of Liaquat National Hospital, Karachi, with limb pains, fulfilling the diagnostic criteria of growing pains, were included. Children with any systemic illness, organic cause of pain, rheumatologic disorders and signs of rickets were excluded from the study. Children were investigated for serum total calcium, inorganic phosphorus, alkaline phosphatase, vitamin D3 (25-hydroxecholecalciferol) and parathormone levels. On the basis of serum vitamin D3 level, patients were divided into 3 groups; group 1 with normal level of vitamin D3 (> 75 nmol/L), group 2 with vitamin D insufficiency (level between 50-75 nmol/L), and group 3 with vitamin D deficiency (level < 50 nmol/L). Significance of group proportions was determined using chi-square test with significance at p < 0.05.

RESULTS: The mean age of the participants was 8.05 years with the majority (59%) being females. Only 6% had normal vitamin D levels. Over 95% of the children with vitamin D insufficiency had normal alkaline phosphatase and parathormone levels.

CONCLUSION: Hypovitaminosis D may have a role in pathogenesis of growing pains. All children with unexplained limb pains without identifiable organic pathology should be tested for vitamin D status, and treated, if necessary. Routine biochemical markers alone are not sufficient to detect all cases of hypovitaminosis D.
PMID: 21575536

CLICK HERE for pdf if you are registered

Restless legs syndrome (Willis-Ekbom disease) and growing pains: are they the same thing?
A side-by-side comparison of the diagnostic criteria for both and recommendations for future research.

Sleep Med. 2013 Sep 26. pii: S1389-9457(13)01108-8. doi: 10.1016/j.sleep.2013.07.013. Epub ahead of print
Walters AS, Gabelia D, Frauscher B.
Department of Neurology, Sleep Division, Vanderbilt University School of Medicine, Nashville, TN, USA. Arthur.Walters at Vanderbilt.edu.

There has been no previous side-by-side comparison of the diagnostic criteria for restless legs syndrome (RLS) (Willis-Ekbom disease) and growing pains. In our review, we explore this comparison emphasizing overlaps and disconnects, summarize recent literature exploring the relationship between the 2 entities, and make suggestions for future research.

There is considerable overlap in the diagnostic criteria for childhood RLS and growing pains.
The literature also indicates that RLS and growing pains more commonly occur together than one would expect based on chance alone, and the family histories of RLS and growing pains often are overlapping.
Leg rubbing to obtain relief from leg discomfort is common to both disorders, though walking to obtain relief seems unique to RLS.
Childhood RLS also has been reported to be painful in up to 45% of cases.
The development of standard diagnostic criteria is necessary to move forward in the field of growing pains research. A quantitative and validated rating scale for growing pains severity already exists. Because of the clinical and genetic similarity between RLS and growing pains, studies that parallel those previously performed in RLS patients are recommended for growing pains patients. For example, a genome wide association study in growing pains patients of all possible genes with particular attention to those identified as related to RLS and a therapeutic trial of medications known to be effective in RLS would be welcome. Abnormalities in vitamin D metabolism also may be common to both disorders.

Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.
PMID: 24157095
Walters AS. Is there a subpopulation of children with growing pains who really have restless legs syndrome? A review of the literature. Sleep Med. 2002;3:93–98
Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisir J. Restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4:101–119
Picchietti DL, Bruni O, de Weerd A, Durmer JS, Kotagal S, Owens JA, et al. Pediatric restless legs syndrome diagnostic criteria: an update by the International Restless Legs Syndrome Study Group. Sleep Med (in press).
International Restless Legs Syndrome Study Group, 2012 revised diagnostic criteria. http://irlssg.org/diagnostic-criteria/ Accessed September 12, 2013.
Evans AM, Scutter SD. Prevalence of “growing pains” in young children. J Pediatr. 2004;145:255–258
Evans AM, Scutter SD. Development of a questionnaire for parental rating of leg pain in young children: internal validity and reliability testing following triangulation. The Foot. 2004;14:42–48
Evans AM. Growing pains: contemporary knowledge and recommended practice. J Foot Ankle Res. 2008;1:4
Champion D, Pathirana S, Flynn C, Taylor A, Hopper JL, Berkovic SF, et al. Growing pains: twin family study evidence for genetic susceptibility and a genetic relationship with restless legs syndrome. Eur J Pain. 2012;16:1224–1231
Peterson HA. Leg aches. Pediatr Clin North Am. 1977;24:731–736
Peterson HA. Growing pains. Pediatr Clin North Am. 1986;33:1365–1372
Picchietti D, Allen RP, Walters AS, Davidson JE, Myers A, Ferini-Strambi L. Restless legs syndrome: prevalence and impact in children and adolescents—The Peds REST study. Pediatrics. 2007;120:253–266
Rajaram SS, Walters AS, England SJ, Mehta D, Nizam F. Some children with growing pains may actually have restless legs syndrome. Sleep. 2004;27:767–773
Chervin RD, Archbold KH, Dillon JE, Pituch KJ, Panahi P, Dahl RE, et al. Associations between symptoms of inattention, hyperactivity, restless legs and periodic leg movements. Sleep. 2002;25:213–218
Balendran J, Champion D, Jaaniste T, Welsh A. A common sleep disorder in pregnancy: restless legs syndrome and its predictors. Aust N Z J Obstet Gynaecol. 2011;51:262–264
Bassetti CL, Mauerhofer D, Gugger M, Mathis J, Hess CW. Restless legs syndrome: a clinical study of 55 patients. Eur Neurol. 2001;45:67–74
Walters AS, Hickey K, Maltzman J, Verrico T, Joseph D, Hening W, et al. A questionnaire study of 138 patients with restless legs syndrome: the ‘Night Walkers’ survey. Neurology. 1996;46:92–95
Walters AS, Picchietti DL, Ehrenberg BL, Wagner ML. Restless legs syndrome in childhood and adolescence. Pediatr Neurol. 1994;11:241–245
Turkdogan D, Bekiroglu N, Zaimoglu S. A prevalence study of restless legs syndrome in Turkish children and adolescents. Sleep Med. 2011;12:315–321
Picchietti DL, Stevens HE. Early manifestations of restless legs syndrome in childhood and adolescence. Sleep Med. 2008;9:770–781
Gamaldo CE, Benbrook AR, Allen RP, Scott JA, Hening WA, Earley CJ. Childhood and adult factors associated with restless legs syndrome (RLS) diagnosis. Sleep Med. 2007;8:716–722
Picchietti DL, Arbuckle RA, Abetz L, Durmer JS, Ivanenko A, Owens JA, et al. Pediatric restless legs syndrome: analysis of symptom descriptions and drawings. J Child Neurol. 2011;26:1365–1376
Brenning R. ‘Growing pains’. Acta Soc Med Upsal. 1960;65:1960
Pavone V, Lionetti E, Gargano V, Evola FR, Costarella L, Sessa G. Growing pains: a study of 30 cases and a review of the literature. J Pediatr Orthop. 2011;31:606–609
Karroum EG, Semenescu S, Arnulf I. Topography of the sensations in primary restless legs syndrome. J Neurol Sci. 2012;320:26–31
Hening WA, Walters AS, Wagner M, Rosen R, Chen V, Kim S, et al. Circadian rhythm of motor restlessness and sensory symptoms in the idiopathic restless legs syndrome. Sleep. 1999;22:901–912
Trenkwalder C, Hening WA, Walters AS, Campbell SS, Rahman K, Chokroverty S. Circadian rhythm of periodic limb movements and sensory symptoms of restless legs syndrome. Mov Disord. 1999;14:102–110
Michaud M, Lavigne G, Desautels A, Poirier G, Montplaisir J. Effects of immobility on sensory and motor symptoms of restless legs syndrome. Mov Disord. 2002;17:112–115
Ekbom KA. Growing pains and restless legs syndrome. Acta Paediatr Scand. 1975;64:264–266
Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, et al. Genome-wide association study of restless legs syndrome identifies common variants in three genome regions. Nat Genet. 2007;39:1000–1006
Schormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, et al. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet. 2008;40:946–948
Walters AS, Picchietti D, Hening W, Lazzarini A. Variable expressivity in familial restless legs syndrome. Arch Neurol. 1990;47:1219–1220
Aurora RN, Kristo DA, Bista SR, Rowley JA, Zak RS, Casey KR, et al. The treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence based review and meta-analysis: An American academy of sleep medicine clinical practice guideline. Sleep. 2012;35:1039–1062
England SJ, Picchietti DL, Couvadelli BV, Fisher BC, Siddiqui F, Wagner ML, et al. L-DOPA improves restless legs syndrome and periodic limb movements but not attention-deficit hyperactivity disorder in a double-blind trial in children. Sleep Med. 2011;12:471–477
Arbuckle R, Abetz L, Durmer JS, Ivanenko A, Owens JA, Croenlein J, et al. Development of the pediatric restless legs syndrome severity scale (P-RLS-SS): a patient-reported outcome measure of pediatric RLS symptoms and impact. Sleep Med. 2010;11:897–906
Walters AS, Lebrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med. 2003;4:121–132
Connor JR, Wang XS, Allen RP, Beard JL, Wiesinger JA, Felt BT, et al. Altered dopaminergic profile in the putamen and substantia nigra in restless legs syndrome. Brain. 2009;132(Pt. 9):2403–2412
Balaban H, Yildiz OK, Cil G, Senturk IA, Erselcan T, Bolayir E, et al. Serum 25-Hydroxy Vitamin D levels in restless legs syndrome patients. Sleep Med. 2012;13:953–957
Qamar S, Akbani S, Shamim S, Khan G. Vitamin D levels in children with growing pains. J. Coll Physicians Surg PAK. 2011;21:284–287
Patton SM, Cho YW, Clardy TW, Allen RP, Earley C, Connor JR. Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome. Fluids Barriers CNS. 2013;10:20

See also VitaminDWiki

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