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COVID-19 harms Mitochondria, Vitamin D normalizes Mitochondria, etc.- Sept 2020

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

Antioxidants 2020, 9(9), 897; https://doi.org/10.3390/antiox9090897
by Natalia de las Heras 1,*OrcID,Virna Margarita Martín Giménez 2,León Ferder 3,Walter Manucha 4,5 and Vicente Lahera 1

VitaminDWiki

See also

  • Vitamin D, Mitochondria, and Muscle - March 2013  PDF
  • Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health - June 2018 -  PDF


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Figure 3. Interplay between mitochondrial dysfunction, RAAS over-activation, and vitamin D levels in the physiopathology of COVID-19. Solid lines indicate stimulation/induction, while dashed lines indicate inhibition/blocking

Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has put the health of the world population on alert. COVID-19 can provoke an acute inflammatory process and uncontrolled oxidative stress, which predisposes one to respiratory syndrome, and in the worst case, death. Recent evidence suggests the mechanistic role of mitochondria and vitamin D in the development of COVID-19. Indeed, mitochondrial dynamics contribute to the maintenance of cellular homeostasis, and its uncoupling involves pathological situations.
SARS-CoV-2 infection is associated with altered mitochondrial dynamics with consequent

  • oxidative stress,
  • pro-inflammatory state,
  • cytokine production, and
  • cell death.

Furthermore, vitamin D deficiency seems to be associated with increased COVID-19 risk.
In contrast, vitamin D can normalize mitochondrial dynamics, which would improve oxidative stress, pro-inflammatory state, and cytokine production.
Furthermore, vitamin D reduces renin–angiotensin–aldosterone system activation and, consequently, decreases ROS generation and improves the prognosis of SARS-CoV-2 infection. Thus, the purpose of this review is to deepen the knowledge about the role of mitochondria and vitamin D directly involved in the regulation of oxidative stress and the inflammatory state in SARS-CoV-2 infection. As future prospects, evidence suggests enhancing the vitamin D levels of the world population, especially of those individuals with additional risk factors that predispose to the lethal consequences of SARS-CoV-2 infection.


Created by admin. Last Modification: Monday September 21, 2020 17:24:01 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
14354 Mitochondria require VDR.pdf admin 21 Sep, 2020 17:19 1.24 Mb 25
14353 Vitamin D, Mitochondria, and Muscle.pdf admin 21 Sep, 2020 17:16 82.54 Kb 25
14352 Mito F3.jpg admin 21 Sep, 2020 17:03 62.05 Kb 62
14351 Mito F2.jpg admin 21 Sep, 2020 17:02 77.88 Kb 56
14350 Mito F1.jpg admin 21 Sep, 2020 17:02 94.35 Kb 56
14349 Mitochondrial Dysfunction in COVID-19.pdf admin 21 Sep, 2020 17:01 865.06 Kb 26
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