Vitamin D Status in Children with Autism Spectrum Disorders: Determinants and Effects of the Response to Probiotic Supplementation
Metabolites. 2022 Jul 1;12(7):611. doi: 10.3390/metabo12070611.
Letizia Guiducci 1, Cristina Vassalle 2, Margherita Prosperi 3, Elisa Santocchi 4, Maria Aurora Morales 1, Filippo Muratori 3 5, Sara Calderoni 3 5
A relationship between the presence of clinical symptoms and gastrointestinal (GI) disturbances associated with nutritional deficiencies, including vitamin D (25(OH)D) deficiency, has been observed in autism spectrum disorder (ASD). The aim was to evaluate 25(OH)D levels according to the annual rhythm cycle, gender, the severity of autism, nutritional or clinical status, inflammatory and metabolic biomarkers, GI symptoms, and the clinical response to probiotic/placebo supplementation in preschooler children with ASD. Eighty-one ASD preschoolers (67 males) were assessed with standardized tools for ASD severity (ADOS score) and GI symptoms (by GI-Index at six-items and at nine-items, the latter defined as the Total GI-Index). The 25(OH)D levels were compared among different ASD subgroups according to metabolic and inflammatory biomarkers (leptin, insulin, resistin, PAI-1, MCP-1, TNF-alfa, and IL-6), gender, and the presence or absence of:
- (i) GI symptoms,
- (ii) the response to probiotic supplementation (the improvement of GI symptomatology),
- (iii) the response to probiotic supplementation (improvement of ASD severity).
Only 25% of the ASD children presented an adequate 25(OH)D status (≥30 ng/mL according to the Endocrine Society guidelines). All the 25(OH)D levels falling in the severe deficiency range (<10 ng/mL) were observed in the male subgroup. A significant inverse correlation between 25(OH)D and leptin was observed (R = -0.24, p = 0.037).
An inverse correlation was found between 25(OH)D levels and the GI Index 6-Items and Total GI-Index (R = -0.25, p = 0.026; -0.27, = 0.009) and a direct relationship with the probiotic response (R = 0.4, p = 0.05).
The monitoring of 25(OH)D levels and the co-administration of 25(OH)D and probiotic supplementation could be considered in ASD from early ages.
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Probiotics helps gastrointentional (GI) problems - common in Autistics
VitaminDWiki pages with PROBIOTICS in title (30 as of July 2022)
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Items found: 33
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Gestational Diabetes best fought by Vitamin D plus probiotics – RCT review Dec 2023 |
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11 Jan, 2024 |
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Feed Additives as Antiviral Agents: Probiotics, Vitamin D, Zn, Se, etc. - Dec 2023 |
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31 Dec, 2023 |
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Rheumatoid Arthritis should be prevented by improving gut microbiota (Vitamin D, probiotics, etc.) – March 2023 |
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18 Mar, 2023 |
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Autism may be synergistically treated by Vitamin D and probiotics – July 2022 |
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27 Jul, 2022 |
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COVID Long-Haul fought by probiotics - Jan 2022 |
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29 Jan, 2022 |
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Tested positive for COVID, taking probiotics stopped symptoms 5 days sooner - RCT Jan 2022 |
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18 Jan, 2022 |
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Probiotics augments Vitamin D – review of RCT Dec 2020 |
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22 Jun, 2021 |
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Microbiome improvement by probiotics can be augmented with phages (gut, etc.) |
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25 Feb, 2021 |
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Vitamin D is aided by probiotics (review of RCTs) – Dec 2020 |
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31 Jan, 2021 |
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New drug application to FDA for a probiotic which might treat COVID-19 – Nov 19, 2020 |
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20 Nov, 2020 |
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Depression treated by Omega-3, Magnesium, Zinc, probiotics, etc - Sept 2017 |
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08 Jan, 2020 |
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Probiotics increased Vitamin D etc in healthy children – RCT Oct 2019 |
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30 Oct, 2019 |
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Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019 |
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21 Feb, 2019 |
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Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018 |
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12 Jan, 2019 |
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If struggling with mental health you may need Omega-3, Vitamin D. Iron, Probiotics, etc. – US News Sept 2018 |
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11 Sep, 2018 |
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Magnesium, Vitamin D, Omega-3, B12, Probiotics are the first of top 10 supplements for senior men - July 2018 |
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21 Jul, 2018 |
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Antibiotics, probiotics |
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22 Nov, 2016 |
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Off topic: Consumer Labs has great reviews of supplements– a peek at their probiotics matrix |
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30 Jul, 2016 |
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Hypothesis: vitamin D and probiotics will reduce type II diabetes – Jan 2013 |
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03 Apr, 2016 |
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Popular supplements 1 Vitamin D, 2 fish oil, 3 CoQ10, 4 multivitamins 5 probiotics - Feb 2016 |
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27 Feb, 2016 |
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Vitamin D receptor functionality improved with probiotics – Sept 2015 |
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02 Sep, 2015 |
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Probiotic and vitamin D synergy - July 2015 |
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11 Jul, 2015 |
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Colon cancer – vitamin D, probiotics, and leptin might help – May 2015 |
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20 May, 2015 |
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Probiotics reduces blood pressure, but not as much as vitamin D does – meta-analysis July 2014 |
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01 Feb, 2015 |
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Probiotic (L. reuteri NCIMB 30242 ) greately increased vitamin D levels for many – RCT July 2013 |
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14 Dec, 2014 |
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Probiotic (L. reuteri NCIMB 30242 ) increased vitamin D levels by 25 percent – RCT July 2013 |
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26 Jul, 2014 |
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Probiotic (Lactobacillus casei Zhang) reduces T2 Diabetes in mice – July 2014 |
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26 Jul, 2014 |
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Probiotics reduced weight gain in mice for many weeks (proof of concept) – June 2014 |
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26 Jul, 2014 |
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Probiotics, prebiotics, and the host microbiome - the science of translation – June 2013 |
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21 Jul, 2014 |
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Probiotic (Lactobacillus reuteri) increased vitamin D levels 22 percent – RCT July 2013 |
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01 Dec, 2013 |
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Probiotics increased vitamin D levels 22 percent in those with excess cholesterol – April 2013 |
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21 May, 2013 |
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Are microbs – probiotics – vitamin D – allergy – asthma – obesity related – Mar 2011 |
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20 Jul, 2011 |
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Many autistic children are getting some Vitamin D, Omega-3, probiotics, etc. - Aug 2019 |
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