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Antimicrobial implications of vitamin D – Oct 2011

Dermato-Endocreinology, Volume 3, Issue 4 October/November/December 2011
Dima A. Youssef, Christopher W.T. Miller, Adel M. El-Abbassi, Della C. Cutchins, Coleman Cutchins, William Grant and Alan N. Peiris

Dima A. Youssef, Mountain Home VAMC Medicine Service; Mountain Home, TN USA
Christopher W.T. Miller, Department of Psychiatry; University of Maryland; Baltimore, MD USA
Adel M. El-Abbassi, Mountain Home VAMC Medicine Service; Mountain Home, TN USA
Della C. Cutchins, Mountain Home VAMC Medicine Service; Mountain Home, TN USA
Coleman Cutchins, East Tennessee State University; College of Pharmacy; Johnson City, TN USA
William Grant, Sunlight, Nutrition, and Health Research Center (SUNARC); San Francisco, CA USA
Alan N. Peiris, Mountain Home VAMC Medicine Service; Mountain Home, TN USA

Evidence exists that vitamin D has a potential antimicrobial activity and its deficiency has deleterious effects on general well-being and longevity. Vitamin D may reduce the risk of infection through multiple mechanisms. Vitamin D boosts innate immunity by modulating production of anti-microbial peptides (AMPs) and cytokine response.

Vitamin D and its analogues via these mechanisms are playing an increasing role in the management of atopic dermatitis, psoriasis, vitiligo, acne and rosacea.

Vitamin D may reduce susceptibility to infection in patients with atopic dermatitis and the ability to regulate local immune and inflammatory responses offers exciting potential for understanding and treating chronic inflammatory dermatitides. Moreover, B and T cell activation as well as boosting the activity of monocytes and macrophages also contribute to a potent systemic anti-microbial effect. The direct invasion by pathogenic organisms may be minimized at sites such as the respiratory tract by enhancing clearance of invading organisms.

A vitamin D replete state appears to benefit most infections, with the possible noteworthy exception of Leishmaniasis. Antibiotics remain an expensive option, and misuse of these agents results in significant antibiotic resistance and contributes to escalating health care costs. Vitamin D constitutes an inexpensive prophylactic option and possibly therapeutic product either by itself or as a synergistic agent to traditional antimicrobial agents. This review outlines the specific antimicrobial properties of vitamin D in combating a wide range of organisms. We discuss the possible mechanisms by which vitamin D may have a therapeutic role in managing a variety of infections.

Figure 1 - Potential interactions of vitamin D

Image

PDF is attached at the bottom of this page


See also VitaminDWiki

See also Web

  • Wikipedia:
    Leishmaniasis is a disease caused by protozoan parasites that belong to the genus Leishmania and is transmitted by the bite of certain species of sand fly

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